ArticleArchives of biochemistry and biophysics2010
Flavin-dependent thymidylate synthase: a novel pathway towards thymine.
Article in Archives of biochemistry and biophysics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Characterization and Genomic Analysis of a Lytic Vibriophage vB_VneS_S3 of Infecting Vibrio neocaledonicus.Current microbiology · 2025Article
- Genome sequences of the firstMicrobial genomics · 2024Article
- A novel long-tailed myovirus represents a new T4-like cyanophage cluster.Frontiers in microbiology · 2023Article
- Newly identified HMO-2011-type phages reveal genomic diversity and biogeographic distributions of this marine viral group.The ISME journal · 2022Article
- Computational Identification of Druggable Bioactive Compounds fromMolecules (Basel, Switzerland) · 2022Article
- N5 Is the New C4a: Biochemical Functionalization of Reduced Flavins at the N5 Position.Frontiers in molecular biosciences · 2020Review
- Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier.Archives of biochemistry and biophysics · 2017Review
- Deprotonations in the Reaction of Flavin-Dependent Thymidylate Synthase.Biochemistry · 2016Article
- Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target.Molecules (Basel, Switzerland) · 2016Review
- Bacillus halodurans Strain C125 Encodes and Synthesizes Enzymes from Both Known Pathways To Form dUMP Directly from Cytosine Deoxyribonucleotides.Applied and environmental microbiology · 2015Article
- Folate binding site of flavin-dependent thymidylate synthase.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Mechanisms and inhibition of uracil methylating enzymes.Bioorganic chemistry · 2012Review
- Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase.Journal of the American Chemical Society · 2012Article
- RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
For several decades only one chemical pathway was known for the de novo biosynthesis of the essential DNA nucleotide, thymidylate. This reaction catalyzed by thyA or TYMS encoded thymidylate synthases is the last committed step in the biosynthesis of thymidylate and proceeds via the reductive methylation of uridylate. However, many microorganisms have recently been shown to produce a novel, flavin-dependent thymidylate synthase encoded by the thyX gene. Preliminary structural and mechanistic studies have shown substantial differences between these deoxyuridylate-methylating enzymes. Recently, both the chemical and kinetic mechanisms of FDTS have provided further insight into the distinctions between thyA and thyX encoded thymidylate synthases. Since FDTSs are found in several severe human pathogens their unusual mechanism offers a promising future for the development of antibiotic and antiviral drugs with little effect on human thymidylate biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.