ArticleRheumatology international2010
Demographic, clinical and mutational characteristics of Turkish familial Mediterranean fever patients: results of a single center in Central Anatolia.
Article in Rheumatology international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- The impact of homozygous mutations in exon 10 on musculoskeletal findings in children with familial mediterranean fever.European journal of pediatrics · 2025Article
- Early Versus Late Onset Familial Mediterranean Fever: Similarities, Discrepancies, and the Value of Neutrophil to Lymphocyte Ratio in Detecting Autoinflammation.Journal of clinical practice and research · 2024Article
- Familial Mediterranean Fever in Spain: Time Trend and Spatial Distribution of the Hospitalizations.International journal of environmental research and public health · 2023Article
- Clinical features, functional status, and quality of life in patients with late-onset familial Mediterranean fever.Northern clinics of Istanbul · 2023Article
- Familial Mediterranean Fever with Neonatal Onset: Case Report.Case reports in pediatrics · 2020Article
- Familial mediterranean fever: assessment of clinical manifestations, pregnancy, genetic mutational analyses, and disease severity in a national cohort.Rheumatology international · 2020Article
- Peripapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in adult-onset familial Mediterranean fever.International ophthalmology · 2018Article
- Frequency of mutations in Mediterranean fever gene, with gender and genotype-phenotype correlations in a Turkish population.Journal of genetics · 2015Article
- MEFV mutations in Northwest of Iran: a cross sectional study.Iranian journal of basic medical sciences · 2015Article
- The frequency of Familial Mediterranean fever gene mutations and genotypes at Kirikkale and comparison with the mean of regional MEFV mutation frequency of Turkey.Molecular biology reports · 2014Article
- Screening of common and novel familial mediterranean fever mutations in south-east part of Turkey.Molecular biology reports · 2014Article
- Enthesopathy in patients with familial Mediterranean fever: increased prevalence in M694 V variant.Rheumatology international · 2013Article
- Familial Mediterranean fever in Germany: epidemiological, clinical, and genetic characteristics of a pediatric population.European journal of pediatrics · 2012Article
- Evaluating MEFV mutation frequency in Turkish familial Mediterranean fever suspected patients and gender correlation: a retrospective study.Molecular biology reports · 2012Article
- Association of clinical and genetical features in FMF with focus on MEFV strip assay sensitivity in 452 children from western Anatolia, Turkey.Clinical rheumatology · 2012Article
- Molecular evaluation of 458 patients referred with a clinical diagnosis of familial Mediterranean fever in Scandinavia.Rheumatology international · 2011Article
- Common Familial Mediterranean Fever gene mutations in a Turkish cohort.Molecular biology reports · 2011Article
- Coexistence of vasculitides with familial Mediterranean fever.Rheumatology international · 2011Review
- Adult-onset familial mediterranean Fever in northwestern iran; clinical feature and treatment outcome.Middle East journal of digestive diseases · 2011Article
- A molecular analysis of familial Mediterranean fever disease in a cohort of Turkish patients.Annals of Saudi medicineArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical and genetic findings of familial Mediterranean fever (FMF) may be variable in different populations. Environmental factors may also affect phenotypic features of FMF. In this study, we investigated demographic, clinical and mutational features of FMF patients who were treated in a single reference hospital in Turkey. Two hundred and sixty patients (169 females, 91 males, mean age 30.44 +/- 10.29 years) were included in this study. All patients were evaluated regarding MEFV gene mutations. The mean age of disease onset was 17.21 +/- 8.66 years (range 2-40 years). The mean duration between the disease onset and diagnosis was 9.39 +/- 8.92 years. Seventy percent of patients had symptoms before 20 years of age (early onset FMF). Arthritis and erysipelas like erythema (ELE) were more common, and the mean duration between the disease onset and diagnosis was longer in early onset FMF patients. The frequency of attacks per year, and disease severity score (DSS) was higher in early onset patients. Homozygote mutation of M694V was detected in 37 (20.2%) and 4 (5.2%) patients in early onset FMF and adult onset FMF groups, respectively (p < 0.05). Histological diagnosis of amyloidosis was established in 7 patients (2.7%). The age of disease onset was earlier, and arthritis and ELE were more frequent, and DSS was higher in patients with M694V/M694V mutation. In conclusion, mean delay to diagnosis in our FMF population is quite high. Early and adult onset forms may differ regarding some clinical, molecular and prognostic characteristics. Disease activity was higher in patients with homozygote mutation of M694V.
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