Evidence map›Paper›PMID 19641918›Full record

Trial reportInternational orthopaedics2010

Use of platelet-rich plasma for the treatment of refractory jumper's knee.

Giuseppe Filardo, Elizaveta Kon, Stefano Della Villa, Ferruccio Vincentelli, Pier Maria Fornasari, Maurilio Marcacci

3 registry-linked trialsAbstract readClinical Trial
In one paragraph

Trial report in International orthopaedics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 79 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01833598 nacompletednot on this mapstarted 2012, after this paper: background citation

The Efficacy of Ultrasound Guided Percutaneous Needle Tenotomy (PNT) Versus Platelet Rich Plasma (PRP) With PNT in the Treatment of Chronic Tendinosis

TypeinterventionalSponsorHospital for Special Surgery, New YorkRan2012 to 2019Enrolled40ConditionsChronic TendinopathyArmsPNT + PRP, PNT alone
NCT02116946 phase2terminatednot on this mapstarted 2014, after this paper: background citation

Intratendinous Injections of Platelet Rich Plasma With or Without Leukocyte Enrichment for Patellar Tendinopathy: a Randomized Controlled Trial

TypeinterventionalSponsorUniversity of British ColumbiaRan2014 to 2018Enrolled64ConditionsPatellar TendinopathyArmsPlatelet Rich Plasma (PRP), Saline + exercise
NCT04350827 nacompletednot on this mapstarted 2020, after this paper: background citation

Platelet-rich Plasma Versus Platelet-rich Plasma Plus Concentrated Insulin-like Growth Factor for Patellar Tendinosis: a Randomized Comparative Trial

TypeinterventionalSponsorOhio State UniversityRan2020 to 2021Enrolled14ConditionsTendinopathy, Patellar Ligament, Platelet-Rich PlasmaArmsPlatelet Rich Plasma, Platelet Rich Plasma plus IGF
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Autologous platelet-rich plasma for assisted reproduction.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Platelet-rich plasma in tendon-related disorders: results and indications.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Platelet-rich therapies for musculoskeletal soft tissue injuries.The Cochrane database of systematic reviews · 2014
    Pooled it
  6. Pooled it
  7. Plasma rich in growth factors (PRGF) as a treatment for high ankle sprain in elite athletes: a randomized control trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Review
  13. Review
  14. Review
  15. Review
  16. Platelet-rich plasma for jumper's knee: a comprehensive review of efficacy, protocols, and future directions.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
    Review
  17. Orthobiologics: a review.International orthopaedics · 2023
    Review
  18. Global Research Trends and Hotspots in Lateral Epicondylitis During the Past 30 Years: A Bibliometric and Visualization Study.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Giuseppe FilardoDepartment of Orthopedic and Sports Trauma, Rizzoli Orthopaedic Institute, Bologna, Italy. g.filardo@biomec.ior.it
Elizaveta Kon
Stefano Della Villa
Ferruccio Vincentelli
Pier Maria Fornasari
Maurilio Marcacci

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate the efficacy of multiple platelet-rich plasma (PRP) injections on the healing of chronic refractory patellar tendinopathy after previous classical treatments have failed. We treated 15 patients affected by chronic jumper's knee, who had failed previous nonsurgical or surgical treatments, with multiple PRP injections and physiotherapy. We also compared the clinical outcome with a homogeneous group of 16 patients primarily treated exclusively with the physiotherapy approach. Multiple PRP injections were performed on three occasions two weeks apart into the site of patellar tendinopathy. Tegner, EQ VAS and pain level were used for clinical evaluation before, at the end of the treatment and at six months follow-up. Complications, functional recovery and patient satisfaction were also recorded. A statistically significant improvement in all scores was observed at the end of the PRP injections in patients with chronic refractory patellar tendinopathy and a further improvement was noted at six months, after physiotherapy was added. Moreover, comparable results were obtained with respect to the less severe cases in the EQ VAS score and pain level evaluation, as in time to recover and patient satisfaction, with an even higher improvement in the sport activity level achieved in the PRP group. The clinical results are encouraging, indicating that PRP injections have the potential to promote the achievement of a satisfactory clinical outcome, even in difficult cases with chronic refractory tendinopathy after previous classical treatments have failed.

Indexed as

Knee JointPlatelet-Rich PlasmaWound HealingAdolescentAdultAthletic InjuriesCase-Control StudiesHumansInjections, Intra-ArticularKnee InjuriesMalePain MeasurementPatient SatisfactionRecovery of FunctionTendinopathyYoung Adult

Identifiers

PMID19641918
PMCPMC2989009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.