ArticleJournal of biomolecular NMR2009
Mesodynamics in the SARS nucleocapsid measured by NMR field cycling.
Article in Journal of biomolecular NMR, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.Nature communications · 2024Article
- The preference signature of the SARS-CoV-2 Nucleocapsid NTD for its 5'-genomic RNA elements.Nature communications · 2023Article
- Convergent views on disordered protein dynamics from NMR and computational approaches.Biophysical journal · 2022Article
- The Role of Disordered Regions in Orchestrating the Properties of Multidomain Proteins: The SARS-CoV-2 Nucleocapsid Protein and Its Interaction with Enoxaparin.Biomolecules · 2022Article
- NMR Reveals Specific Tracts within the Intrinsically Disordered Regions of the SARS-CoV-2 Nucleocapsid Protein Involved in RNA Encountering.Biomolecules · 2022Article
- The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region.Journal of molecular biology · 2021Article
- How wide is the window opened by high-resolution relaxometry on the internal dynamics of proteins in solution?Journal of biomolecular NMR · 2021Article
- Boosting the resolution of low-fieldJournal of biomolecular NMR · 2020Article
- High sensitivity high-resolution full range relaxometry using a fast mechanical sample shuttling device and a cryo-probe.Journal of biomolecular NMR · 2016Article
- Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probed by High Resolution Field Cycling 31P NMR Relaxometry.The Journal of biological chemistry · 2016Article
- The SARS coronavirus nucleocapsid protein--forms and functions.Antiviral research · 2014Review
- Nanosecond time scale motions in proteins revealed by high-resolution NMR relaxometry.Journal of the American Chemical Society · 2013Article
- Functional transcriptional regulatory sequence (TRS) RNA binding and helix destabilizing determinants of murine hepatitis virus (MHV) nucleocapsid (N) protein.The Journal of biological chemistry · 2012Article
- High-resolution NMR field-cycling device for full-range relaxation and structural studies of biopolymers on a shared commercial instrument.Journal of biomolecular NMR · 2012Article
- Electron-nuclear interactions as probes of domain motion in proteins.The Journal of chemical physics · 2010Article
- A topical issue: NMR investigations of molecular dynamics.Journal of biomolecular NMR · 2009Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Protein motions on all timescales faster than molecular tumbling are encoded in the spectral density. The dissection of complex protein dynamics is typically performed using relaxation rates determined at high and ultra-high field. Here we expand this range of the spectral density to low fields through field cycling using the nucleocapsid protein of the SARS coronavirus as a model system. The field-cycling approach enables site-specific measurements of R (1) at low fields with the sensitivity and resolution of a high-field magnet. These data, together with high-field relaxation and heteronuclear NOE, provide evidence for correlated rigid-body motions of the entire beta-hairpin, and corresponding motions of adjacent loops with a time constant of 0.8 ns (mesodynamics). MD simulations substantiate these findings and provide direct verification of the time scale and collective nature of these motions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.