ArticleExperimental and clinical cardiology2003
Cardiac myosin phenotype remodelling following adrenodemedullectomy and chronic 6-hydroxydopamine in male Sprague-Dawley rats.
Article in Experimental and clinical cardiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors at 1 institution in 1 country.
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Abstract
backgroundAn increase was previously found in relative beta myosin heavy chain (MyHC) in the right ventricle of rats following thoracic spinal transection. It was hypothesized that the MyHC remodelling that was observed might be due, in part, to autonomic influences on the right ventricle.
objectiveTo evaluate cardiac myosin phenotype following 21 days of reduced sympathetic activity.
methodsAdult male Sprague-Dawley rats underwent either adrenodemedullectomy/chemical sympathectomy (SX) or sham operation/sham injection (CN). Twenty-one days following surgery, the animals were sacrificed and both ventricles were harvested. The ventricles were denatured and run on sodium dodecyl sulfate-polyacrylamide gel electrophoresis for identification of MyHC isoforms.
resultsSX resulted in a significant decline in catecholamines. In the right ventricle, beta MyHC ratio was twofold higher in SX animals than in CN rats, but there was no difference between groups in beta MyHC concentration in the left ventricle (P<0.05). Uniquely, we found a decrease in relative alpha MyHC in the right ventricle but no change in the myosin phenotype in the left ventricle.
conclusionsThese data potentially indicate that MyHC concentrations in the left ventricle are less sensitive than the right ventricle to decreased sympathetic activity.
Indexed as
Identifiers
19641706PMC2716275W2305482091What OpenQuestion holds
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