ArticleExperimental and clinical cardiology2004
Therapeutic potentials of pentoxifylline for treatment of cardiovascular diseases.
Article in Experimental and clinical cardiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Adverse effects of the PENTO(CLO) protocol in the prevention and management of iatrogenic head and neck bone necrosis in cancer patients: A systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Effect of pentoxifylline on serum levels and gene expression of inflammatory markers: a systematic review and meta-analysis of randomized controlled trials.Inflammopharmacology · 2025Pooled it
- Pentoxifylline in COVID-19 and considerations for its research in long COVID.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Pooled it
- Pentoxifylline for the prevention of contrast-induced nephropathy in diabetic patients undergoing angioplasty: a randomized controlled trial.International urology and nephrology · 2019Trial
- A pilot randomized trial of pentoxifylline for the reduction of periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention.European journal of clinical pharmacology · 2015Trial
- Amikacin toxicity revisited: pentoxifylline offers protection in high-risk treatment scenarios.AMB Express · 2025Article
- Efficacy of Combination of Intralesional Pentoxifylline and Dexamethasone with Intralesional Pentoxifylline, Intralesional Dexamethasone alone in the Treatment of Oral Submucous Fibrosis- A Pilot Study.Journal of maxillofacial and oral surgery · 2025Article
- Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Assessing Mailuoning injection in wound healing and thrombophlebitis management: A rat model study.International wound journal · 2024Article
- Effect of pentoxifylline on endothelial dysfunction, oxidative stress and inflammatory markers in STEMI patients.Future science OA · 2024Article
- Pentoxifylline changes the balance of immune cell population in breast tumor-infiltrating lymphocytes.Medical oncology (Northwood, London, England) · 2023Article
- Review
- A raising dawn of pentoxifylline in management of inflammatory disorders in Covid-19.Inflammopharmacology · 2022Review
- Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm.Journal of clinical medicine · 2021Review
- Inflammation in Human Heart Failure: Major Mediators and Therapeutic Targets.Frontiers in physiology · 2021Review
- Therapeutic efficacy of pentoxifylline on proteinuria and renal progression: an update.Journal of biomedical science · 2017Review
- Salinivibrio costicola GL6, a Novel Isolated Strain for Biotransformation of Caffeine to Theobromine Under Hypersaline Conditions.Current microbiology · 2017Article
- Central Renin-Angiotensin System Activation and Inflammation Induced by High-Fat Diet Sensitize Angiotensin II-Elicited Hypertension.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Effect of pentoxifylline on histopathological changes in steroid-induced osteonecrosis of femoral head: experimental study in chicken.International orthopaedics · 2012Article
- The effects of pentoxifylline administration on NFΚB P50 transcription factor expression.ARYA atherosclerosis · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular diseases are life-threatening conditions and, thus, have received a great deal of attention over the years. Several mechanisms, including hemorheology changes and inflammatory effects, are considered to be involved in the pathogenesis of these diseases. Because cardiovascular dysfunction is also known to worsen hemorheology changes and influence vital symptoms, it has become critical to formulate effective therapeutic strategies to combat the deleterious effects of cardiovascular diseases. Although a wide variety of drugs have been developed for the treatment of cardiovascular diseases, the effectiveness of any agent for therapy of a given disease cannot be indicated with certainty. OBJECTIVES AND OBSERVATIONS: Pentoxifylline (PTXF), a phosphodiesterase inhibitor, has been investigated for close to two decades because of its primary pharmacological actions on hemorheology and other anti-inflammatory effects. Several studies have been conducted to investigate the effects and mechanisms of PTXF in ischemic injury, peripheral vascular disease and heart failure. The present article is intended to emphasize the therapeutic potentials of PTXF in different types of cardiovascular diseases, focusing on the mechanisms of its pharmacological actions.
Indexed as
Identifiers
19641695PMC2716262W93288809What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.