ArticleExperimental and clinical cardiology2004
The role of free radicals in endogenous adaptation and intracellular signals.
Article in Experimental and clinical cardiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- FLASH-RT for pulmonary protection: a comprehensive review of mechanisms, technological advances, and clinical translation.Frontiers in oncology · 2025Review
- Changes in the blood antioxidant defense of advanced age people.Clinical interventions in aging · 2019Article
- Remote post-conditioning and allopurinol reduce ischemia-reperfusion injury in an infra-renal ischemia model.Therapeutic advances in cardiovascular disease · 2018Article
- Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3β Signaling Cascades and Afferent Arteriolar Activity.Kidney & blood pressure research · 2018Article
- Glutamine prevents oxidative stress in a model of portal hypertension.World journal of gastroenterology · 2017Article
- Ginsenoside Rb1 attenuates intestinal ischemia reperfusion induced renal injury by activating Nrf2/ARE pathway.Molecules (Basel, Switzerland) · 2012Article
- Effects of penehyclidine hydrochloride in small intestinal damage caused by limb ischemia-reperfusion.World journal of gastroenterology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress can generate a mass of oxygen free radicals (OFR) in the cells, and these OFRs can induce several acute and chronic symptoms and diseases. If the amount of the generated OFRs overwhelms the antioxidant capacity of the cells, the pathophysiological changes may lead to the death of the cell or the development of chronic degenerative diseases.The phenomenon of ischemic preconditioning has demonstrated the important role of these aggressive and harmful molecules in the endogenous adaptation mechanism of the cells to oxidative stress. After sublethal oxidative stress - mild ischemic insult - the resulting development of a few OFRs can stimulate the intracellular signal-transduction cascade of ischemic preconditioning and, through the induction of severe transcription factors, new antioxidant enzymes and heat shock proteins will be synthesized. These newly synthesized proteins will protect the cellagainst another, more serious oxidative insult in the future.
Indexed as
Identifiers
19641690PMC2716256W2184912343What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.