ArticleExperimental and clinical cardiology2005
Role of tumour necrosis factor-alpha and other cytokines in ischemia-reperfusion-induced injury in the heart.
Article in Experimental and clinical cardiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 69 citations in OpenAlex.
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- Risk of cardiovascular disease associated with use of tumor necrosis factor inhibitors in ankylosing spondylitis.Journal of rheumatic diseases · 2026Article
- Ursodeoxycholic acid as a potential cardioprotective agent: molecular mechanisms, experimental evidence, and clinical perspectives.Frontiers in pharmacology · 2026Review
- The role of antioxidant and anti-inflammatory mechanisms in the protective effects of vigabatrin against ovarian ischemia-reperfusion injury in a rat model.Journal of ovarian research · 2025Article
- Involvement of Oxidative Stress and Antioxidants in Modification of Cardiac Dysfunction Due to Ischemia-Reperfusion Injury.Antioxidants (Basel, Switzerland) · 2025Review
- Cardioprotective action of apocynin in isoproterenol-induced cardiac damage is mediated through Nrf-2/HO-1 signaling pathway.Food science & nutrition · 2024Article
- Effect of umbilical cord mesenchymal stem cell-derived mitochondrial transplantation on ischemia-reperfusion injury in a rat model.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- The Multifaceted Nature of Macrophages in Cardiovascular Disease.Biomedicines · 2024Review
- The Role of Pro-Inflammatory Cytokines in the Pathogenesis of Cardiovascular Disease.International journal of molecular sciences · 2024Review
- Inflammation in Heart Failure-Future Perspectives.Journal of clinical medicine · 2023Review
- Clinical Applications for Gasotransmitters in the Cardiovascular System: Are We There Yet?International journal of molecular sciences · 2023Review
- Drug-based mobilisation of mesenchymal stem/stromal cells improves cardiac function post myocardial infarction.Disease models & mechanisms · 2023Article
- Role of Oxidative Stress in Cardiac Dysfunction and Subcellular Defects Due to Ischemia-Reperfusion Injury.Biomedicines · 2022Review
- Histone deacetylase HDAC4 participates in the pathological process of myocardial ischemia-reperfusion injury via MEKK1/JNK pathway by binding to miR-206.Cell death discovery · 2021Article
- Alarming Cargo: The Role of Exosomes in Trauma-Induced Inflammation.Biomolecules · 2021Review
- Anti-IL-20 Antibody Protects against Ischemia/Reperfusion-Impaired Myocardial Function through Modulation of Oxidative Injuries, Inflammation and Cardiac Remodeling.Antioxidants (Basel, Switzerland) · 2021Article
- Cardiac Arrest Induced by Asphyxia Versus Ventricular Fibrillation Elicits Comparable Early Changes in Cytokine Levels in the Rat Brain, Heart, and Serum.Journal of the American Heart Association · 2021Article
- Inflammation in Human Heart Failure: Major Mediators and Therapeutic Targets.Frontiers in physiology · 2021Review
- Vildagliptin reduces myocardial ischemia-induced arrhythmogenesis via modulating inflammatory responses and promoting expression of genes regulating mitochondrial biogenesis in rats with type-II diabetes.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2020Article
- Baicalin regulates macrophages polarization and alleviates myocardial ischaemia/reperfusion injury via inhibiting JAK/STAT pathway.Pharmaceutical biology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral investigations have implicated cytokines such as tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-1, IL-6, IL-8 and transforming growth factor-beta in the pathophysiology of cellular dysfunction in ischemia-reperfusion (I/R). Although an increase in the production of these cytokines has been detected after myocardial infarction and cardiopulmonary bypass surgery, their exact role and mechanisms for inducing cardiac dysfunction are poorly understood. OBSERVATIONS: TNF-alpha, transforming growth factor-beta, IL-1, IL-6 and IL-8 have frequently been studied in different cardiovascular diseases, including I/R injury in the heart. Low concentrations of TNF-alpha appear to exert cardioprotective effects, whereas high concentrations have been shown to produce deleterious actions in the heart. Some efforts have been made to explore the molecular mechanisms of cytokine actions; however, such information is insufficient to develop therapeutic strategies to combat their deleterious effects during the development of I/R injury in the heart.
conclusionsIn addition to a time-dependent response, the conflicting effects of cytokines seem to depend on their concentrations used in different experimental studies. It is also likely that both the beneficial and pathophysiological actions of cytokines occur concomitantly. On the basis of the existing literature, it is suggested that different ways need to be found to modify the synthesis as well as the cardiodepressant actions of cytokines to improve the therapy of ischemic heart disease.
Indexed as
Identifiers
19641672PMC2716235W183149861What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.