ArticleExperimental and clinical cardiology2005
Effects of cigarette smoke, nicotine and cotinine on red blood cell hemolysis and their -SH capacity.
Article in Experimental and clinical cardiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- The Effect of a Secondary Stressor on the Morphology and Membrane Structure of an Already Challenged Maternal and Foetal Red Blood Cell Population.International journal of molecular sciences · 2025Article
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- Genetically influenced tobacco and alcohol use behaviors impact erythroid trait variation.PloS one · 2024Article
- Impacts of cigarette smoking on blood circulation: do we need a new approach to blood donor selection?Journal of health, population, and nutrition · 2023Review
- Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney CellsOxidative medicine and cellular longevity · 2022Article
- Electronic cigarette solvents, pulmonary irritation, and endothelial dysfunction: role of acetaldehyde and formaldehyde.American journal of physiology. Heart and circulatory physiology · 2021Article
- Atomic force microscopy and Raman spectra profile of blood components associated with exposure to cigarette smoking.RSC advances · 2020Article
- Article
- Detection of Nicotine and Nicotine Metabolites in Units of Banked Blood.American journal of clinical pathology · 2019Article
- Impact of Diabetes Mellitus on Human Erythrocytes: Atomic Force Microscopy and Spectral Investigations.International journal of environmental research and public health · 2018Article
- Nanostructural Changes in the Cell Membrane of Gamma-Irradiated Red Blood Cells.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2017Article
- Smoking Induced Hemolysis: Spectral and microscopic investigations.Scientific reports · 2016Article
- Erythrocyte Antioxidant Defenses Against Cigarette Smoking in Ischemic Heart Disease.Journal of clinical and diagnostic research : JCDR · 2015Article
- The effects of water pipe smoking on hematological parameters in rats.International journal of hematology-oncology and stem cell research · 2014Article
- Effect of Oxidative Phytochemicals on Nicotine-stressed UMNSAH/DF-1 Cell Line.Journal of traditional and complementary medicine · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmoking is a leading cause of premature death. Red blood cell (RBC) membrane lipids are rich in polyunsaturated fatty acids; therefore, the effect of oxygen on RBC membranes is more prominent than on other body tissues. The attachment of peroxidants to RBC membranes can result in hemolysis.
objectivesThe present study was conducted to assess the sensitivity of RBCs to 2,2'-azo-bis-(2-amidinopropane) dihydrochloride in smokers and nonsmokers. The effect of cigarette smoke, nicotine (1 mug/mL, 1.5 mug/mL and 2.5 mug/mL) and cotinine (1.25 mug/mL, 2.5 mug/mL and 5 mug/mL) on RBC hemolysis was also examined.
resultsRBC hemolysis in smokers was 21.6% higher than in non-smokers (P<0.05). Cigarette smoke increased 2,2'-azo-bis-(2-amidino-propane) dihydrochloride-induced RBC hemolysis by 281.7%. Nicotine inhibited RBC hemolysis by 36.7% at the highest concentration used, but increased RBC hemolysis at the lower concentrations. Cotinine caused a 13.8% increase in RBC membrane peroxidation at the highest concentration used and its effects were dose-dependent. At their highest concentrations, nicotine and cotinine decreased -SH groups by 50%.
conclusionsThe present study confirms the results from previous studies of the oxidative and destructive effects of cigarette smoke, which are detrimental to the health of both active and passive smokers.
Indexed as
Identifiers
19641671PMC2716233W196400518What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.