ArticlePloS one2009
Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Genetic, Socioecological, and Health Research on Extreme Longevity in Semisupercentenarians and Supercentenarians: A Scoping Review.Journal of aging research · 2026Article
- Mapping and editing animal mitochondrial genomes: can we overcome the challenges?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population.Frontiers in genetics · 2020Article
- Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study.Clinical interventions in aging · 2020Article
- Mitochondrial genetic haplogroups and cardiovascular diseases: Data from the Osteoarthritis Initiative.PloS one · 2019Article
- Contribution of Mitochondrial DNA Variation to Chronic Disease in East Asian Populations.Frontiers in molecular biosciences · 2019Review
- Bagging Nearest-Neighbor Prediction independence Test: an efficient method for nonlinear dependence of two continuous variables.Scientific reports · 2017Article
- Demographics, phenotypic health characteristics and genetic analysis of centenarians in China.Mechanisms of ageing and development · 2017Review
- Mitochondrial DNA mutations and cardiovascular disease.Current opinion in cardiology · 2017Article
- Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis.Scientific reports · 2017Article
- Does Low Body Mass Index Matter? Relationship between Body Mass Index and Subjective Well-Being among Long-Lived Women over 95 Years of Age.The journal of nutrition, health & aging · 2016Article
- Use of serum albumin and activities of daily living to predict mortality in long-lived individuals over 95 years of age: a population-based study.Age (Dordrecht, Netherlands) · 2015Article
- Mitochondrial genomes and exceptional longevity in a Chinese population: the Rugao longevity study.Age (Dordrecht, Netherlands) · 2015Article
- Mitochondrial DNA haplogroup D4b is a protective factor for ischemic stroke in Chinese Han population.Molecular genetics and genomics : MGG · 2014Article
- Association between subjective well-being and exceptional longevity in a longevity town in China: a population-based study.Age (Dordrecht, Netherlands) · 2014Article
- Mito-nuclear co-evolution: the positive and negative sides of functional ancient mutations.Frontiers in genetics · 2014Review
- Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity.International journal of molecular sciences · 2013Review
- Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration.Molecular vision · 2013Article
- Physiology and pathophysiology of mitochondrial DNA.Advances in experimental medicine and biology · 2012Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLongevity is a multifactorial trait with a genetic contribution, and mitochondrial DNA (mtDNA) polymorphisms were found to be involved in the phenomenon of longevity. METHODOLOGY/PRINCIPAL
findingsTo explore the effects of mtDNA haplogroups on the prevalence of extreme longevity (EL), a population based case-control study was conducted in Rugao--a prefecture city in Jiangsu, China. Case subjects include 463 individuals aged > or = 95 yr (EL group). Control subjects include 926 individuals aged 60-69 years (elderly group) and 463 individuals aged 40-49 years (middle-aged group) randomly recruited from Rugao. We observed significant reduction of M9 haplogroups in longevity subjects (0.2%) when compared with both elderly subjects (2.2%) and middle-aged subjects (1.7%). Linear-by-linear association test revealed a significant decreasing trend of N9 frequency from middle-aged subjects (8.6%), elderly subjects (7.2%) and longevity subjects (4.8%) (p = 0.018). In subsequent analysis stratified by gender, linear-by-linear association test revealed a significant increasing trend of D4 frequency from middle-aged subjects (15.8%), elderly subjects (16.4%) and longevity subjects (21.7%) in females (p = 0.025). Conversely, a significant decreasing trend of B4a frequency was observed from middle-aged subjects (4.2%), elderly subjects (3.8%) and longevity subjects (1.7%) in females (p = 0.045).
conclusionsOur observations support the association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.
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