ArticleBiology of reproduction2009
Differential effects of follistatin on nonhuman primate oocyte maturation and pre-implantation embryo development in vitro.
Article in Biology of reproduction, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Chimpanzee and pig-tailed macaque iPSCs: Improved culture and generation of primate cross-species embryos.Cell reports · 2022Article
- Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state.PLoS biology · 2022Article
- Follistatin supplementation induces changes in CDX2 CpG methylation and improves in vitro development of bovine SCNT preimplantation embryos.Reproductive biology and endocrinology : RB&E · 2021Article
- Follistatin treatment modifies DNA methylation of the CDX2 gene in bovine preimplantation embryos.Molecular reproduction and development · 2020Article
- Role of bone morphogenetic protein signaling in bovine early embryonic development and stage specific embryotropic actions of follistatin†.Biology of reproduction · 2020Article
- Follistatin supplementation during in vitro embryo culture improves developmental competence of bovine embryos produced using sex-sorted semen.Reproductive biology · 2018Article
- Functional role of AKT signaling in bovine early embryonic development: potential link to embryotrophic actions of follistatin.Reproductive biology and endocrinology : RB&E · 2018Article
- Evidence supporting a role for SMAD2/3 in bovine early embryonic development: potential implications for embryotropic actions of follistatin.Biology of reproduction · 2015Article
- Maternal control of early embryogenesis in mammals.Reproduction, fertility, and development · 2015Review
- Expression of TGFβ superfamily components and other markers of oocyte quality in oocytes selected by brilliant cresyl blue staining: relevance to early embryonic development.Molecular reproduction and development · 2015Article
- Temporal regulation of mRNAs for select bone morphogenetic proteins (BMP), BMP receptors and their associated SMAD proteins during bovine early embryonic development: effects of exogenous BMP2 on embryo developmental progression.Reproductive biology and endocrinology : RB&E · 2014Article
- Article
- Embryotropic actions of follistatin: paracrine and autocrine mediators of oocyte competence and embryo developmental progression.Reproduction, fertility, and development · 2013Article
- Global gene expression profiling of individual human oocytes and embryos demonstrates heterogeneity in early development.PloS one · 2013Article
- Primate preimplantation embryo is a target for relaxin during early pregnancy.Fertility and sterility · 2011Article
- Reprogrammed transcriptome in rhesus-bovine interspecies somatic cell nuclear transfer embryos.PloS one · 2011Article
- The follistatin-288 isoform alone is sufficient for survival but not for normal fertility in mice.Endocrinology · 2010Article
- Ontological aspects of pluripotency and stemness gene expression pattern in the rhesus monkey.Gene expression patterns : GEPArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
There is a vital need to identify factors that enhance human and nonhuman primate in vitro embryo culture and outcome, and to identify the factors that facilitate that objective. Granulosa and cumulus cells were obtained from rhesus monkeys that had either been FSH-primed (in vitro maturation [IVM]) or FSH and hCG-primed (in vivo maturation [VVM]) and compared for the expression of mRNAs encoding follistatin (FST), inhibin, and activin receptors. The FST mRNA displayed marginally decreased expression (P = 0.05) in association with IVM in the granulosa cells. The ACVR1B mRNA was more highly expressed in cumulus cells with IVM compared with VVM. Cumulus-oocyte complexes from FSH-primed monkeys exposed to exogenous FST during the 24-h IVM period exhibited no differences in the percentage of oocytes maturing to the metaphase II stage of meiosis compared to controls. However, embryos from these oocytes had significantly decreased development to the blastocyst stage. The effect of FST on early embryo culture was determined by exposing fertilized VVM oocytes to exogenous FST from 12 to 60 h postinsemination. FST significantly improved time to first cleavage and embryo development to the blastocyst stage compared with controls. The differential effects of exogenous FST on embryo development, when administered before and after oocyte maturation, may depend on the endogenous concentration in cumulus cells and oocytes. These results reveal evolutionary conservation of a positive effect of FST on embryogenesis that may be broadly applicable to enhance in vitro embryogenesis, with potential application to human clinical outcome and livestock and conservation biology.
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