ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Poly-(ADP-ribose) polymerase-1 is necessary for long-term facilitation in Aplysia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Poly ADP-ribosylation regulates Arc expression and promotes adaptive stress-coping.Psychopharmacology · 2025Article
- Acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific benefits.Frontiers in rehabilitation sciences · 2024Article
- Role of NADCellular and molecular neurobiology · 2023Review
- A Ribosomal Perspective on Neuronal Local Protein Synthesis.Frontiers in molecular neuroscience · 2022Review
- Sex differences in Alzheimer's disease: Understanding the molecular impact.Brain research · 2019Review
- Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment.Neural plasticity · 2019Article
- PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation.The Journal of cell biology · 2018Article
- Article
- PARP-1 is required for retrieval of cocaine-associated memory by binding to the promoter of a novel gene encoding a putative transposase inhibitor.Molecular psychiatry · 2017Article
- A transcriptomics approach uncovers novel roles for poly(ADP-ribosyl)ation in the basal defense response in Arabidopsis thaliana.PloS one · 2017Article
- A PARP1-ERK2 synergism is required for the induction of LTP.Scientific reports · 2016Article
- Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease: Consequences for Epigenetic Regulation of rDNA and Cognition.Neural plasticity · 2016Article
- A PARP1-Erk2 synergism is required for stimulation-induced expression of immediate early genes.Gene & translational bioinformatics · 2016Article
- PARP-1 activity is required for the reconsolidation and extinction of contextual fear memory.Molecular brain · 2015Article
- Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury.Journal of neurotrauma · 2014Article
- Cellular and subcellular localization of PKMζ.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- Nucleolar integrity is required for the maintenance of long-term synaptic plasticity.PloS one · 2014Article
- Active DNA demethylation in post-mitotic neurons: a reason for optimism.Neuropharmacology · 2013Review
- Cellular, molecular, and epigenetic mechanisms in non-associative conditioning: implications for pain and memory.Neurobiology of learning and memory · 2013Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Activity-dependent long-term synaptic plasticity requires gene expression and protein synthesis. Identifying essential genes and studying their transcriptional and translational regulation are key steps to understanding how synaptic changes become long lasting. Recently, the enzyme poly-(ADP-ribose) polymerase 1 (PARP-1) was shown to be necessary for long-term memory (LTM) in Aplysia. Since PARP-1 decondenses chromatin, we hypothesize that this enzyme regulates the expression of specific genes essential for long-term synaptic plasticity that underlies LTM. We cloned Aplysia PARP-1 (ApPARP-1) and determined that its expression in sensory neurons is necessary for serotonin (5-HT)-mediated long-term facilitation (LTF) of sensorimotor neuron synapses. PARP enzymatic activity is also required, since transient application of PARP inhibitors blocked LTF. Differential display and RNA analysis of ganglia dissected from intact animals exposed to 5-HT identified the ribosomal RNA genes as PARP-dependent effector genes. The increase in the expression of rRNAs is long lasting and dynamic. Pulse-labeling RNA studies showed a PARP-dependent increase in rRNAs but not in the total RNA 24 h after 5-HT treatment. Moreover, the expression of both the AprpL27a (Aplysia ribosomal protein L27a) and the ApE2N (Aplysia ubiquitin-conjugating enzyme E2N) mRNAs also increased after 5-HT. Thus, our results suggest that 5-HT, in part by regulating PARP-1 activity, alters the expression of transcripts required for the synthesis of new ribosomes necessary for LTF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.