ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
L-type voltage-dependent calcium channel antagonists impair perirhinal long-term recognition memory and plasticity processes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Epigenomic aberrations of histone methylation in prefrontal cortex of humans with mild cognitive impairment and Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Perirhinal to prefrontal circuit in methamphetamine induced recognition memory deficits.Neuropharmacology · 2023Article
- Detecting Fear-Memory-Related Genes from Neuronal scRNA-seq Data by Diverse Distributions and Bhattacharyya Distance.Biomolecules · 2022Article
- Intracellular emetic signaling evoked by the L-type CaEuropean journal of pharmacology · 2018Article
- Pharmacological Strategies for Manipulating Plant CaInternational journal of molecular sciences · 2018Review
- Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1.Molecular neurobiology · 2017Review
- Verapamil Blocks Scopolamine Enhancement Effect on Memory Consolidation in Passive Avoidance Task in Rats.Frontiers in pharmacology · 2017Article
- Mechanisms of memory storage in a model perirhinal network.Brain structure & function · 2017Article
- L-type Ca²⁺ channel blockade with antihypertensive medication disrupts VTA synaptic plasticity and drug-associated contextual memory.Molecular psychiatry · 2016Article
- In search of a recognition memory engram.Neuroscience and biobehavioral reviews · 2015Review
- BDNF release is required for the behavioral actions of ketamine.The international journal of neuropsychopharmacology · 2014Article
- Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.American journal of physiology. Cell physiology · 2014Article
- Hippocampal molecular mechanisms involved in the enhancement of fear extinction caused by exposure to novelty.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Nitric oxide-dependent long-term depression but not endocannabinoid-mediated long-term potentiation is crucial for visual recognition memory.The Journal of physiology · 2013Article
- Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans.eLife · 2013Article
- Synaptic depression in the CA1 region of freely behaving mice is highly dependent on afferent stimulation parameters.Frontiers in integrative neuroscience · 2013Article
- What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory.Neuropsychologia · 2012Review
- Interfering with Fos expression in rat perirhinal cortex impairs recognition memory.Hippocampus · 2012Article
- Dual functions of perirhinal cortex in fear conditioning.Hippocampus · 2012Review
- MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex.The European journal of neuroscience · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The perirhinal cortex of the temporal lobe is essential for the familiarity discrimination component of recognition memory. In view of the importance of changes in calcium ion concentration for synaptic plasticity, the present study examined the effects of L-type voltage-dependent calcium channel (VDCC) antagonism on rat perirhinal-based familiarity discrimination processes and plasticity including long-term depression (LTD), long-term potentiation (LTP), and depotentiation. Single doses of three different types of L-type VDCC antagonists, verapamil, diltiazem, and nifedipine, administered systemically, or verapamil administered locally into the perirhinal cortex, impaired acquisition of long-term (24 h) but not shorter-term (20 min) recognition memory. L-type VDCC antagonism also disrupted memory retrieval after 24 h but not 20 min. Differential neuronal activation produced by viewing novel or familiar visual stimuli was measured by Fos expression. L-type VDCC antagonism by verapamil in perirhinal cortex during memory acquisition disrupted the normal pattern of differential Fos expression, so paralleling the antagonist-induced memory impairment. In slices of perirhinal cortex maintained in vitro, verapamil was without effect on baseline excitability or LTP but blocked LTD and depotentiation. The consistency of effects across the behavioral and cellular levels of analysis provides strong evidence for the involvement of perirhinal L-type VDCCs in long-term recognition memory processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.