ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Synergistic antiallodynic effects of pregabalin and thioctic acid in a rat model of neuropathic pain.Frontiers in pharmacology · 2025Article
- Does Oxidative Stress Along with Dysbiosis Participate in the Pathogenesis of Asthma in the Obese?Cell biochemistry and biophysics · 2023Article
- T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions.Frontiers in pharmacology · 2023Review
- Experience with nutraceutical supplements in the treatment of pelvic pain in gynaecology: case reports.Drugs in context · 2022Article
- Alpha lipoic acid attenuates evoked and spontaneous pain following surgical skin incision in rats.Channels (Austin, Tex.) · 2021Article
- Unique cysteine-enriched, D2L5 and D4L6 extracellular loops in CaScientific reports · 2020Article
- Delineating an extracellular redox-sensitive module in T-type CaThe Journal of biological chemistry · 2020Article
- Glycosylation of CaFrontiers in cellular neuroscience · 2020Article
- Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for α-Lipoic Acid.Frontiers in pharmacology · 2019Article
- Efficacy of dietary supplement with nutraceutical composed combined with extremely-low-frequency electromagnetic fields in carpal tunnel syndrome.Journal of physical therapy science · 2018Article
- Combination Analgesic Development for Enhanced Clinical Efficacy (CADENCE Trial): Study Protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of an Alpha-Lipoic Acid - Pregabalin Combination for the Treatment of Fibromyalgia Pain.JMIR research protocols · 2017Article
- Pain Improvement With Novel Combination Analgesic Regimens (PAIN-CARE): Randomized Controlled Trial Protocol.JMIR research protocols · 2017Article
- Levetiracetam synergizes with gabapentin, pregabalin, duloxetine and selected antioxidants in a mouse diabetic painful neuropathy model.Psychopharmacology · 2017Article
- Innovations in the Management of Musculoskeletal Pain With Alpha-Lipoic Acid (IMPALA Trial): Study protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of Alpha-Lipoic Acid for the Treatment of Fibromyalgia Pain.JMIR research protocols · 2017Article
- Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone.Psychopharmacology · 2014Article
- Redox regulation of neuronal voltage-gated calcium channels.Antioxidants & redox signaling · 2014Review
- T-type calcium channels in chronic pain: mouse models and specific blockers.Pflugers Archiv : European journal of physiology · 2014Review
- Clinical usefulness of oral supplementation with alpha-lipoic Acid, curcumin phytosome, and B-group vitamins in patients with carpal tunnel syndrome undergoing surgical treatment.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- An approach to identify microRNAs involved in neuropathic pain following a peripheral nerve injury.Frontiers in neuroscience · 2014Article
- Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.Antioxidants & redox signaling · 2013Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Alpha-lipoic acid (1,2-dithiolane-3-pentanoic acid; lipoic acid) is an endogenous compound used to treat pain disorders in humans, but its mechanisms of analgesic action are not well understood. Here, we show that lipoic acid selectively inhibited native Ca(V)3.2 T-type calcium currents (T-currents) and diminished T-channel-dependent cellular excitability in acutely isolated rat sensory neurons. Lipoic acid locally injected into peripheral receptive fields of pain-sensing sensory neurons (nociceptors) in vivo decreased sensitivity to noxious thermal and mechanical stimuli in wild-type but not Ca(V)3.2 knock-out mice. Ensuing molecular studies demonstrated that lipoic acid inhibited recombinant Ca(V)3.2 channels heterologously expressed in human embryonic kidney 293 cells by oxidating specific thiol residues on the cytoplasmic face of the channel. This study provides the first mechanistic demonstration of a nociceptive ion channel modulation that may contribute to the documented analgesic properties of lipoic acid in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.