ArticleJournal of clinical microbiology2009
Prospective comparison of eubacterial PCR and measurement of procalcitonin levels with blood culture for diagnosing septicemia in intensive care unit patients.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Society of Critical Care Medicine and the Infectious Diseases Society of America Guidelines for Evaluating New Fever in Adult Patients in the ICU.Critical care medicine · 2023Pooled it
- Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections.Antimicrobial agents and chemotherapy · 2011Pooled it
- Diagnosing Sepsis and Identifying Bacterial Resistance Genes Directly from Whole Blood Using a Rapid Real-Time PCR System.International journal of molecular sciences · 2026Article
- Nanomaterials for bacterial enrichment and detection in healthcare.Nanomedicine (London, England) · 2025Review
- Early identification of bloodstream infection in hemodialysis patients by machine learning.Heliyon · 2023Article
- Necrotizing Fasciitis: Pillaging the Acute Phase Response.The Journal of bone and joint surgery. American volume · 2020Review
- The combined rapid detection and species-level identification of yeasts in simulated blood culture using a colorimetric sensor array.PloS one · 2017Article
- Levels of serum procalcitonin and C-reactive protein for evaluating pulmonary bacterial infection in patients with lupus erythematosus.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Article
- Clinical evaluation of multiple inflammation biomarkers for diagnosis and prognosis for patients with systemic inflammatory response syndrome.Journal of clinical microbiology · 2014Article
- Procalcitonin versus C-reactive protein: Usefulness as biomarker of sepsis in ICU patient.International journal of critical illness and injury science · 2014Article
- Characteristics of hospital-acquired and community-onset blood stream infections, South-East Austria.PloS one · 2014Article
- Biomarkers for sepsis: a review with special attention to India.BioMed research international · 2014Review
- Persistent systemic inflammation in chronic critical illness.Respiratory care · 2012Review
- Utility of procalcitonin as an early diagnostic marker of bacteremia in patients with acute fever.Yonsei medical journal · 2011Article
- Multiplex blood PCR in combination with blood cultures for improvement of microbiological documentation of infection in febrile neutropenia.Journal of clinical microbiology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid identification of infection has a major impact on the clinical course, management, and outcome of critically ill intensive care unit (ICU) patients. We compared the results of PCR and procalcitonin with blood culture for ICU patients suspected of having septicemia. Ninety patients (60 patients meeting the criteria for sepsis and 30 patients not meeting the criteria for sepsis) were evaluated. Compared with blood culture as the gold standard, the sensitivity, specificity, and positive and negative predictive values for PCR were 100%, 43.33%, 46.87%, and 100%, respectively, and for procalcitonin were 100%, 61.66%, 56.6%, and 100%, respectively. The average times required to produce a final result were as follows: PCR, 10 h; blood culture, 33 h; procalcitonin, 45 min. Both PCR and procalcitonin may be useful as rapid tests for detecting septicemia but compared with blood cultures lacked specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.