ArticleDevelopment (Cambridge, England)2009
Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- A computational framework to study EGFR signaling distribution in egg chambers during dynamic interactions between soma and germline.PLoS computational biology · 2025Article
- Diversity ofFrontiers in cell and developmental biology · 2025Article
- ETS transcription factors regulate precise matrix metalloproteinase expression and follicle rupture in Drosophila.Development (Cambridge, England) · 2024Article
- Finishing the egg.Genetics · 2024Article
- Stochastic phenotypes in RAS-dependent developmental diseases.Current biology : CB · 2023Article
- A Unifying Framework for Understanding Biological Structures and Functions Across Levels of Biological Organization.Integrative and comparative biology · 2022Article
- The ETS-transcription factor Pointed is sufficient to regulate the posterior fate of the follicular epithelium.Development (Cambridge, England) · 2020Article
- Quantitative analyses of EGFR localization and trafficking dynamics in the follicular epithelium.Development (Cambridge, England) · 2020Article
- The proneural wave in theeLife · 2019Article
- Two Drosophilids exhibit distinct EGF pathway patterns in oogenesis.Development genes and evolution · 2018Article
- Simple Expression Domains Are Regulated by Discrete CRMs DuringG3 (Bethesda, Md.) · 2017Article
- Gene regulation duringProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.Developmental cell · 2017Review
- Transforming Growth Factor β/activin signalling induces epithelial cell flattening during Drosophila oogenesis.Biology open · 2015Article
- Evolutionary changes in TGFα distribution underlie morphological diversity in eggshells from Drosophila species.Development (Cambridge, England) · 2014Article
- A discrete model of Drosophila eggshell patterning reveals cell-autonomous and juxtacrine effects.PLoS computational biology · 2014Article
- A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling.Developmental biology · 2014Article
- Dynamic model for the coordination of two enhancers of broad by EGFR signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Co-option of a coordinate system defined by the EGFr and Dpp pathways in the evolution of a morphological novelty.EvoDevo · 2013Article
- Molecular mechanisms of EGF signaling-dependent regulation of pipe, a gene crucial for dorsoventral axis formation in Drosophila.Development genes and evolution · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The morphogenesis of structures with repeated functional units, such as body segments and appendages, depends on multi-domain patterns of cell signaling and gene expression. We demonstrate that during Drosophila oogenesis, the two-domain expression pattern of Broad, a transcription factor essential for the formation of the two respiratory eggshell appendages, is established by a single gradient of EGFR activation that induces both Broad and Pointed, which mediates repression of Broad. Two negative-feedback loops provided by the intracellular inhibitors of EGFR signaling, Kekkon-1 and Sprouty, control the number and position of Broad-expressing cells and in this way influence eggshell morphology. Later in oogenesis, the gradient of EGFR activation is split into two smaller domains in a process that depends on Argos, a secreted antagonist of EGFR signaling. In contrast to the previously proposed model of eggshell patterning, we show that the two-domain pattern of EGFR signaling is not essential for specifying the number of appendages. Thus, the processes that define the two-domain patterns of Broad and EGFR activation are distinct; their actions are separated in time and have different effects on eggshell morphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.