Trial reportThe American journal of clinical nutrition2009
Alcohol consumption and diabetes risk in the Diabetes Prevention Program.
Trial report in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00038727. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diabetes Prevention Program Outcomes Study
Open the trial in the graphWho cites it
28 citing papers in PubMed.
- A High-Carbohydrate, High-Fiber, Low-Fat Diet Results in Weight Loss among Adults at High Risk of Type 2 Diabetes.The Journal of nutrition · 2017Trial
- Low-, medium- and high-glycaemic index carbohydrates and risk of type 2 diabetes in men.The British journal of nutrition · 2011Trial
- Behavioral and Sociodemographic Predictors of Diabetes Among Non-Hispanic Multiracial Adults in the United States: Using the 2023 Behavioral Risk Factor Surveillance System.International journal of environmental research and public health · 2025Article
- The association between metabolic syndrome severity and frailty risk in patients with rheumatoid arthritis: a cross-sectional study.Arthritis research & therapy · 2025Article
- Prevalence and predictors of chronic disease among rural and medically underserved populations using smokeless tobacco.Frontiers in public health · 2025Article
- Prevalence and sociodemographic correlates of antinuclear antibody testing by indirect immunofluorescence or solid-phase assays in a Spanish population: the Camargo Cohort.Immunologic research · 2024Article
- Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review.Communications medicine · 2023Article
- Association between metal mixture exposure and abnormal glucose metabolism in multiple mixture exposure models: Evidence from NHANES 2015-2016.Current research in toxicology · 2023Article
- The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS).BMC nutrition · 2022Article
- Higher fasting triglyceride predicts higher risks of diabetes mortality in US adults.Lipids in health and disease · 2021Article
- Alcohol and Metabolic-associated Fatty Liver Disease.Journal of clinical and translational hepatology · 2021Review
- Framingham Risk Score Assessment in Subjects with Pre-diabetes and Diabetes: A Cross-Sectional Study in Korea.Journal of obesity & metabolic syndrome · 2021Article
- Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men.Journal of diabetes investigation · 2021Article
- Review
- Games and Health Education for Diabetes Control: A Systematic Review with Meta-Analysis.Healthcare (Basel, Switzerland) · 2020Review
- Alcohol Consumption and Risk of Chronic Kidney Disease: A Nationwide Observational Cohort Study.Nutrients · 2019Observational
- Alcohol Consumption, Diabetes Risk, and Cardiovascular Disease Within Diabetes.Current diabetes reports · 2017Review
- The Relationship between Alcohol Consumption and Incidence of Glycometabolic Abnormality in Middle-Aged and Elderly Chinese Men.International journal of endocrinology · 2016Article
- Therapeutic Use of Metformin in Prediabetes and Diabetes Prevention.Drugs · 2015 · on this mapReview
- Factors affecting the decline in incidence of diabetes in the Diabetes Prevention Program Outcomes Study (DPPOS).Diabetes · 2015Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundModerate alcohol consumption is associated with a decreased risk of type 2 diabetes in the general population, but little is known about the effects in individuals at high risk of diabetes.
objectivesThe objectives were to determine associations between alcohol consumption and diabetes risk factors and whether alcohol consumption was a predictor of incident diabetes in individuals enrolled in the Diabetes Prevention Program (DPP).
designDPP participants (n = 3175) had impaired glucose tolerance (2-h glucose: 7.8-11.1 mmol/L), elevated fasting glucose (5.3-7.0 mmol/L), and a body mass index (in kg/m(2)) > or =24. Participants were randomly assigned to placebo, metformin, or lifestyle modification and were followed for a mean of 3.2 y. Alcohol intake was assessed at baseline and year 1 by using a semiquantitative food-frequency questionnaire. Diabetes was diagnosed by annual oral-glucose-tolerance testing and semiannual fasting plasma glucose measurement.
resultsParticipants who reported higher alcohol consumption tended to be male, older, white, and less obese and to have a higher calorie intake and a higher HDL-cholesterol concentration. Higher alcohol consumption was associated with lower insulin secretion at any level of insulin sensitivity. We found lower incidence rates of diabetes with higher alcohol consumption in the metformin (P < 0.01 for trend) and lifestyle modification (P = 0.02 for trend) groups, which remained significant after adjustment for multiple baseline covariates. No similar association was observed in the placebo group.
conclusionsDespite overall low rates of alcohol consumption, there was a reduced risk of incident diabetes in those who reported modest daily alcohol intake and were assigned to metformin or lifestyle modification. Moderate daily alcohol intake is associated with lower insulin secretion-an effect that warrants further investigation. This trial was registered at clinicaltrials.gov as NCT00038727.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.