ArticleBioorganic & medicinal chemistry letters2009
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
Article in Bioorganic & medicinal chemistry letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs.Nature chemistry · 2025Article
- Synthesis and characterization of high affinity fluorogenic α-synuclein probes.Chemical communications (Cambridge, England) · 2020Article
- Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer's disease.Scientific reports · 2018Article
- The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of Aβ(1-42) with Cu ions.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2013Article
- Reactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species.Inorganic chemistry · 2012Article
- Dye-binding assays for evaluation of the effects of small molecule inhibitors on amyloid (aβ) self-assembly.ACS chemical neuroscience · 2012Review
- Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease.Cold Spring Harbor perspectives in medicine · 2012Review
- Bifunctional compounds for controlling metal-mediated aggregation of the aβ42 peptide.Journal of the American Chemical Society · 2012Article
- Dihydroxybenzoic acid isomers differentially dissociate soluble biotinyl-Aβ(1-42) oligomers.Biochemistry · 2012Article
- Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.Inorganic chemistry · 2011Article
- Insight into amyloid structure using chemical probes.Chemical biology & drug design · 2011Review
- The neurotransmitter serotonin interrupts α-synuclein amyloid maturation.Biochimica et biophysica acta · 2011Article
- Quantifying prefibrillar amyloids in vitro by using a "thioflavin-like" spectroscopic method.Chembiochem : a European journal of chemical biology · 2010Article
- Small molecule modulators of copper-induced Abeta aggregation.Journal of the American Chemical Society · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligomers and linear fibrils, which possess distinct biological activities. However, known chemical probes, including the dyes thioflavin T and Congo Red, appear to lack selectivity for specific amyloid structures. To identify molecules that might differentiate between these architectures, we employed a fluorescence-based interaction assay to screen a collection of 68 known Abeta ligands against pre-formed oligomers and fibrils. In these studies, we found that the fluorescence of five indole-based compounds was selectively quenched ( approximately 15%) in the presence of oligomers, but remained unchanged after addition of fibrils. These results suggest that indoles might be complementary to existing chemical probes for studying amyloid formation in vitro.
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