Evidence map›Paper›PMID 19640271›Full record

Trial reportTrials2009

Clinical evaluation of magnetic resonance imaging in coronary heart disease: the CE-MARC study.

John P Greenwood, Neil Maredia, Aleksandra Radjenovic, Julia M Brown, Jane Nixon, Amanda J Farrin, Catherine Dickinson, John F Younger, John P Ridgway, Mark Sculpher and 2 more

Open access · goldAbstract readComparative StudyRandomized Controlled TrialValidation Study
In one paragraph

Trial report in Trials, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 64 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Individual component analysis of the multi-parametric cardiovascular magnetic resonance protocol in the CE-MARC trial.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2015
    Trial
  5. Considerations when measuring myocardial perfusion reserve by cardiovascular magnetic resonance using regadenoson.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2012
    Trial
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Exercise cardiovascular magnetic resonance: development, current utility and future applications.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

John P GreenwoodDivision of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds General Infirmary, Leeds, LS1 3EX, UK. j.greenwood@leeds.ac.uk
Neil Maredia
Aleksandra Radjenovic
Julia M Brown
Jane Nixon
Amanda J Farrin
Catherine Dickinson
John F Younger
John P Ridgway
Mark Sculpher
Stephen G Ball
Sven Plein
University of Leeds · GBLeeds General Infirmary · GBLeeds Teaching Hospitals NHS Trust · GBUniversity of York · GB

Funding

British Heart Foundation RG/05/004
6 · The paper itself

Abstract

backgroundSeveral investigations are currently available to establish the diagnosis of coronary heart disease (CHD). Of these, cardiovascular magnetic resonance (CMR) offers the greatest information from a single test, allowing the assessment of myocardial function, perfusion, viability and coronary artery anatomy. However, data from large scale studies that prospectively evaluate the diagnostic accuracy of multi-parametric CMR for the detection of CHD in unselected populations are lacking, and there are few data on the performance of CMR compared with current diagnostic tests, its prognostic value and cost-effectiveness. METHODS/

designThis is a prospective diagnostic accuracy cohort study of 750 patients referred to a cardiologist with suspected CHD. Exercise tolerance testing (ETT) will be preformed if patients are physically able. Recruited patients will then undergo CMR and single photon emission tomography (SPECT) followed in all patients by invasive X-ray coronary angiography. The order of the CMR and SPECT tests will be randomised. The CMR study will comprise rest and adenosine stress perfusion, cine imaging, late gadolinium enhancement and whole-heart MR coronary angiography. SPECT will use a gated stress/rest protocol. The primary objective of the study is to determine the diagnostic accuracy of CMR in detecting significant coronary stenosis, as defined by X-ray coronary angiography. Secondary objectives include an assessment of the prognostic value of CMR imaging, a comparison of its diagnostic accuracy against SPECT and ETT, and an assessment of cost-effectiveness. DISCUSSION: The CE-MARC study is a prospective, diagnostic accuracy cohort study of 750 patients assessing the performance of a multi-parametric CMR study in detecting CHD using invasive X-ray coronary angiography as the reference standard and comparing it with ETT and SPECT.

trial registrationCurrent Controlled Trials ISRCTN77246133.

Indexed as

Coronary AngiographyCoronary DiseaseHumansMagnetic Resonance ImagingPrognosisReproducibility of ResultsResearch DesignTomography, Emission-Computed, Single-Photon

Identifiers

PMID19640271
PMCPMC3224948
OpenAlexW2095592276

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.