ArticleJournal of biomechanical engineering2009
Strain-dependent oxygen diffusivity in bovine annulus fibrosus.
Article in Journal of biomechanical engineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Article
- Patient-specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs.JOR spine · 2021Article
- Diffusion of antibiotics in intervertebral disc.Journal of biomechanics · 2018Article
- Effect of mechanical strain on solute diffusion in human TMJ discs: an electrical conductivity study.Annals of biomedical engineering · 2013Article
- Nutrient transport in human annulus fibrosus is affected by compressive strain and anisotropy.Annals of biomedical engineering · 2012Article
- Cell viability in intervertebral disc under various nutritional and dynamic loading conditions: 3d finite element analysis.Journal of biomechanics · 2012Article
- Effect of mechanical loading on electrical conductivity in porcine TMJ discs.Journal of dental research · 2011Article
- Difference in Energy Metabolism of Annulus Fibrosus and Nucleus Pulposus Cells of the Intervertebral Disc.Cellular and molecular bioengineering · 2011Article
- Relationship between solute transport properties and tissue morphology in human annulus fibrosus.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2009Article
- Effect of mechanical loading on electrical conductivity in human intervertebral disk.Journal of biomechanical engineering · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The intervertebral disk (IVD) is the largest avascular structure in the human body. Transport of small molecules in IVD is mainly through diffusion from the endplates and the peripheral blood vessels surrounding IVD. Studies have investigated the structure, chemical components, and water content in IVD, but to our knowledge no study has investigated the effect of mechanical loading on oxygen transport in IVD. The objective of this study was to determine the strain-dependent behavior of oxygen diffusivity in IVD tissue. A one-dimensional steady-state diffusion experiment was designed and performed to determine the oxygen diffusivity in bovine annulus fibrosus (AF). The oxygen diffusivity was calculated using equation derived from Fick's law. A total of 20 AF specimens (d=6 mm, h approximately 0.5 mm) from bovine coccygeal IVD were used to determine oxygen diffusivity at three levels of compressive strain. The average oxygen diffusivity (mean+/-SD) of bovine AF in the axial direction was 1.43+/-0.242 x 10(-5) cm(2)/s (n=20) at 4.68+/-1.67% compressive strain level, 1.05+/-0.282 x 10(-5) cm(2)/s (n=20) at 14.2+/-1.50% strain level, and 7.71+/-1.63 x 10(-6) cm(2)/s (n=20) at 23.7+/-1.34% strain level. There was a significant decrease in oxygen diffusivity with increasing level of compressive strain (ANOVA, p<0.05). Oxygen diffusivity of bovine AF in the axial direction has been determined. The mechanical loading has a significant effect on oxygen transport in IVD tissues. This study is important in understanding nutritional transport in IVD tissues and related disk degeneration.
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Registered trials
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