Evidence map›Paper›PMID 19640002›Full record

ArticleNano letters2009

A high-performance nanobio photocatalyst for targeted brain cancer therapy.

Elena A Rozhkova, Ilya Ulasov, Barry Lai, Nada M Dimitrijevic, Maciej S Lesniak, Tijana Rajh

Open access · greenAbstract read
In one paragraph

Article in Nano letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 278 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Sonocatalytic Optimization of Titanium-Based Therapeutic Nanomedicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Nanotechnology: A Potential Weapon to Fight against COVID-19.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2022
    Review
  11. Article
  12. Reactive Oxygen Species-Regulating Strategies Based on Nanomaterials for Disease Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  13. Article
  14. Dopamine-Decorated TiOJournal of chemical theory and computation · 2020
    Article
  15. Article
  16. TETT-functionalized TiONanoscale advances · 2020
    Article
  17. Article
  18. Proton Transfers at a Dopamine-Functionalized TiOThe journal of physical chemistry. C, Nanomaterials and interfaces · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elena A RozhkovaThe Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA. rozhkova@anl.gov
Ilya Ulasov
Barry Lai
Nada M Dimitrijevic
Maciej S Lesniak
Tijana Rajh
University of Chicago · USArgonne National Laboratory · US

Funding

Regulatory T Cells and Oncolytic Virotherapy of GliomaR01CA122930 · NCI · UNIVERSITY OF CHICAGO · PI LESNIAK, MACIEJ S · 2008 to 2015
$2.5M
Targeted Adenoviral Gene Therapy for Malignant GliomaK08NS046430 · NINDS · UNIVERSITY OF CHICAGO · PI LESNIAK, MACIEJ S · 2005 to 2009
$829k
Development of an Adenoviral Vector with Chimeric Fiber for Malignant GliomaR21CA135728 · NCI · UNIVERSITY OF CHICAGO · PI LESNIAK, MACIEJ S · 2008 to 2009
$388k
NCI NIH HHS R01 CA122930NCI NIH HHS R01-CA122930NCI NIH HHS R21 CA135728NCI NIH HHS R21- CA135728NINDS NIH HHS K08 NS046430NINDS NIH HHS K08-NS046430
6 · The paper itself

Abstract

We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO(2) particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.

Indexed as

Antibodies, MonoclonalBrain NeoplasmsCatalysisCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansHydroquinonesMaterials TestingModels, BiologicalNanoparticlesNanotechnologyParticle SizePhotochemistrySurface PropertiesTitaniumAntibodies, MonoclonalHydroquinonesTitaniumtitanium dioxide

Identifiers

PMID19640002
PMCPMC4019973
OpenAlexW2000186632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.