ArticleHuman brain mapping2010
Neural correlates of efficacy of voice therapy in Parkinson's disease identified by performance-correlation analysis.
Article in Human brain mapping, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
38 citing papers in PubMed, 107 citations in OpenAlex.
- The Acoustic Voice Quality Index (AVQI) in People with Parkinson's Disease Before and After Intensive Voice and Articulation Therapies: Secondary Outcome of a Randomized Controlled Trial.Journal of voice : official journal of the Voice Foundation · 2024Trial
- Immediate and long-term effects of speech treatment targets and intensive dosage on Parkinson's disease dysphonia and the speech motor network: Randomized controlled trial.Human brain mapping · 2022Trial
- Speech treatment in Parkinson's disease: Randomized controlled trial (RCT).Movement disorders : official journal of the Movement Disorder Society · 2018Trial
- Intensive voice treatment (LSVT®LOUD) for Parkinson's disease following deep brain stimulation of the subthalamic nucleus.Journal of communication disordersTrial
- Speech Impairment in Early Parkinson's Disease Is Associated with Nigrostriatal Dopaminergic Dysfunction.Journal of clinical medicine · 2026Article
- Disorders of the Basal Ganglia and Cerebellum: A Comprehensive Review of Speech Sensorimotor Symptoms and Responses to Feedback Perturbations.Neurobiology of language (Cambridge, Mass.) · 2026Review
- The Effectiveness of Lee Silverman Voice Treatment (LSVT LOUD) on Children's Speech and Voice: A Scoping Review.Brain sciences · 2024Article
- Speech and neuroimaging effects following HiCommunication: a randomized controlled group intervention trial in Parkinson's disease.Brain communications · 2024Article
- Narrative analysis in individuals with Parkinson's disease following intensive voice treatment: secondary outcome variables from a randomized controlled trial.Frontiers in human neuroscience · 2024Article
- Premotor cortex is hypoactive during sustained vowel production in individuals with Parkinson's disease and hypophonia.Frontiers in human neuroscience · 2023Article
- Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation.Frontiers in neuroscience · 2023Article
- Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson's disease.Frontiers in aging neuroscience · 2022Article
- Article
- Effects of Lee Silverman Voice Treatment (LSVT LOUD) on Swallowing in Patients with Progressive Supranuclear Palsy: A Pilot Study.Progress in rehabilitation medicine · 2021Article
- Neurobehavioral Effects of LSVTFrontiers in neuroscience · 2021Article
- Brain morphological changes in hypokinetic dysarthria of Parkinson's disease and use of machine learning to predict severity.CNS neuroscience & therapeutics · 2020Article
- The effects of intensive speech treatment on intelligibility in Parkinson's disease: A randomised controlled trial.EClinicalMedicine · 2020Article
- Mapping typical and hypokinetic dysarthric speech production network using a connected speech paradigm in functional MRI.NeuroImage. Clinical · 2020Article
- Lee Silverman voice treatment (LSVT) mitigates voice difficulties in mild Parkinson's disease.Medical journal of the Islamic Republic of Iran · 2019Article
- Internal cueing improves gait more than external cueing in healthy adults and people with Parkinson disease.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
LSVT LOUD (Lee Silverman Voice Treatment) is efficacious in the treatment of speech disorders in idiopathic Parkinson's disease (IPD), particularly hypophonia. Functional imaging in patients with IPD has shown abnormalities in several speech regions and changes in these areas immediately following treatment. This study serves to extend the analysis by correlating changes of regional neural activity with the main behavioral change following treatment, namely, increased vocal intensity. Ten IPD participants with hypophonia were studied before and after LSVT LOUD. Cerebral blood flow during rest and reading conditions were measured by H(2)(15)O-positron emission tomography. Z-score images were generated by contrasting reading with rest conditions for pre- and post-LSVT LOUD sessions. Neuronal activity during reading in the pre- versus post-LSVT LOUD contrast was correlated with corresponding change in vocal intensity to generate correlation images. Behaviorally, vocal intensity for speech tasks increased significantly after LSVT LOUD. The contrast and correlation analyses indicate a treatment-dependent shift to the right hemisphere with modification in the speech motor regions as well as in prefrontal and temporal areas. We interpret the modification of activity in these regions to be a top-down effect of LSVT LOUD. The absence of an effect of LSVT LOUD on the basal ganglion supports this argument. Our findings indicate that the therapeutic effect of LSVT LOUD in IPD hypophonia results from a shift in cortical activity to the right hemisphere. These findings demonstrate that the short-term changes in the speech motor and multimodal integration areas can occur in a top-down manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.