ReviewActa oncologica (Stockholm, Sweden)2009
Tumor-associated epilepsy and glioma: are there common genetic pathways?
Review in Acta oncologica (Stockholm, Sweden), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Seizures in children with dysembryoplastic neuroepithelial tumors of the brain--A review of surgical outcomes across several studies.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Pooled it
- Clinical, oncological, and seizure outcomes following surgery for hippocampal gliomas: A systematic review and meta-analysis.Surgical neurology international · 2026Review
- Molecular mechanisms and diagnostic model of glioma-related epilepsy.NPJ precision oncology · 2024Article
- [Epilepsy in cancer patients: primary prevention and the importance of high-risk patient screening].Revista de neurologia · 2022Review
- The persistence of seizures after tumor resection negatively affects survival in low-grade glioma patients: a clinical retrospective study.Journal of neurology · 2022Article
- Correlation of Clinicopathological Factors with Brain Tumor-Related Epilepsy in Glioma.Disease markers · 2022Article
- New strategies for managing adult gliomas.Journal of neurology · 2021Review
- Old Stars and New Players in the Brain Tumor Microenvironment.Frontiers in cellular neuroscience · 2021Review
- Development of a Rat Model for Glioma-Related Epilepsy.International journal of molecular sciences · 2020Article
- Factors associated with seizure and cognitive outcomes after epilepsy surgery for low-grade epilepsy-associated neuroepithelial tumors in children.Clinical and experimental pediatrics · 2020Article
- Prediction of comorbid diseases using weighted geometric embedding of human interactome.BMC medical genomics · 2019Article
- IDH mutations but not TERTp mutations are associated with seizures in lower-grade gliomas.Medicine · 2018Article
- Brain Tumor-Related Epilepsy: a Current Review of the Etiologic Basis and Diagnostic and Treatment Approaches.Current neurology and neuroscience reports · 2017Review
- Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma‑associated epilepsy.Molecular medicine reports · 2015Article
- Expression of RINT1 predicts seizure occurrence and outcomes in patients with low-grade gliomas.Journal of cancer research and clinical oncology · 2015Article
- Deficiency of very large G-protein-coupled receptor-1 is a risk factor of tumor-related epilepsy: a whole transcriptome sequencing analysis.Journal of neuro-oncology · 2015Article
- Peritumoral epilepsy: relating form and function for surgical success.Epilepsy & behavior : E&B · 2014Review
- Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme.Neuro-oncology · 2013Article
- Seizures in low-grade gliomas: natural history, pathogenesis, and outcome after treatments.Neuro-oncology · 2012Review
- Brain tumor-related epilepsy.Current neuropharmacology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPatients with glioma exhibit a great variability in clinical symptoms apart from variations in response to therapy and survival. Many patients present with epileptic seizures at disease onset, especially in case of low-grade gliomas, but not all have seizures. A large proportion of patients develop refractory seizures. It is likely that the variability in epileptic symptoms cannot exclusively be explained by tumor-related factors, but rather reflects complex interaction between tumor-related, environmental and hereditary factors. MATERIAL AND
methodsNo data exist on susceptibility genes associated with epileptic symptoms in patients with glioma. However, an increasing number of candidate genes have been proposed for other focal epilepsies such as temporal lobe epilepsy. Some of the susceptibility candidate genes associated with focal epilepsy may contribute to epileptic symptoms also in patients with glioma.
resultsThis review presents an update on studies on genetic polymorphisms and focal epilepsy and brings forward putative candidate genes for tumor-associated epilepsy, based on the assumption that common etiological pathways may exist for glioma development and glioma-associated seizures. Conclusion. Genes involved in the immune response, in synaptic transmission and in cell cycle control are discussed that may play a role in the pathogenesis of tumor growth as well as epileptic symptoms in patients with gliomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.