ReviewDocumenta ophthalmologica. Advances in ophthalmology2010
The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model.
Review in Documenta ophthalmologica. Advances in ophthalmology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 80 citations in OpenAlex.
- Imaging of the retinal hypoxia: A journey from oxygen microelectrode to the first hypoxia imaging in the living retina.Progress in retinal and eye research · 2025Review
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- Increase in methemoglobin fraction due to the use of glyceryl trinitrate patches in preterm infants: a case report and literature review.Frontiers in pediatrics · 2025Article
- Inhibitory effects of ursolic acid on oxygen-induced mouse retinal neovascularization via intravitreal injection.Molecular vision · 2025Article
- Longitudinal analysis of carotenoid content in preterm human milk.European journal of pediatrics · 2024Article
- Extending Peripheral Retinal Vascularization in Retinopathy of Prematurity Through Regulation of VEGF Signaling.American journal of ophthalmology · 2024Article
- Editorial: Identification of novel biomarkers for retinopathy of prematurity in preterm infants by use of innovative technologies and artificial intelligence.Frontiers in pediatrics · 2024Article
- Pathophysiology of Retinopathy of Prematurity.Annual review of vision science · 2023Review
- Modifiable Risk Factors and Preventative Strategies for Severe Retinopathy of Prematurity.Life (Basel, Switzerland) · 2023Review
- An imbalance in autophagy contributes to retinal damage in a rat model of oxygen-induced retinopathy.Journal of cellular and molecular medicine · 2021Article
- Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis.Human gene therapy · 2021Article
- Investigating the effects of carvacrol in rats using oxygen-induced retinopathy model.Indian journal of ophthalmology · 2021Article
- Inhibition of retinal neovascularization by VEGF siRNA delivered via bioreducible lipid-like nanoparticles.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Retinopathy of Prematurity: Evolving Treatment With Anti-Vascular Endothelial Growth Factor.American journal of ophthalmology · 2020Review
- Protective Effects and Molecular Signaling of n-3 Fatty Acids on Oxidative Stress and Inflammation in Retinal Diseases.Antioxidants (Basel, Switzerland) · 2020Review
- CCN1-Yes-Associated Protein Feedback Loop Regulates Physiological and Pathological Angiogenesis.Molecular and cellular biology · 2019Article
- Oxidative stress upregulates Wnt signaling in human retinal microvascular endothelial cells through activation of disheveled.Journal of cellular biochemistry · 2019Article
- Intermittent hypoxemia and oxidative stress in preterm infants.Respiratory physiology & neurobiology · 2019Review
- Three-dimensional pattern of extraretinal neovascular development in retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Microarray Analysis of Long Non-Coding RNAs and Messenger RNAs in a Mouse Model of Oxygen-Induced Retinopathy.International journal of medical sciences · 2019Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The objective of this study is to determine growth factor expression and activation of signaling pathways associated with intravitreous neovascularization and peripheral avascular retina using a model of retinopathy of prematurity (ROP) relevant to today with oxygen monitoring in neonatal units. Studies using 50/10 oxygen-induced retinopathy (OIR) and 50/10 OIR+SO models were reviewed. Repeated fluctuations in oxygen increased retinal vascular endothelial growth factor (VEGF) even while peripheral avascular retina persisted and prior to the development of intravitreous neovascularization. Repeated fluctuations in oxygen increased VEGF(164) expression but not VEGF(120). Neutralizing VEGF bioactivity significantly reduced intravitreous neovascularization and arteriolar tortuosity without interfering with ongoing retinal vascularization. Repeated oxygen fluctuations led to retinal hypoxia and increased reactive oxygen species (ROS). Inhibiting ROS with NADPH oxidase inhibitor, apocynin, reduced avascular retina by interfering with apoptosis. Supplemental oxygen reduced retinal VEGF concentration and exacerbated NADPH oxidase activation to contribute to intravitreous neovascularization through activation of the JAK/STAT pathway. Oxygen stresses relevant to those experienced by preterm infants today trigger signaling of different pathways to cause avascular retina and intravitreous neovascularization. Increased signaling of VEGF appears important to the development of both avascular retina and intravitreous neovascularization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.