ReviewJournal of leukocyte biology2009
Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells.
Review in Journal of leukocyte biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- In silico discovery of 3 novel quercetin derivatives against papain-like protease, spike protein, and 3C-like protease of SARS-CoV-2.Journal, genetic engineering & biotechnology · 2022Article
- High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Healing after COVID-19: are survivors at risk for pulmonary fibrosis?American journal of physiology. Lung cellular and molecular physiology · 2021Review
- Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19.International journal of inflammation · 2021Review
- Anthraquinone Derivatives as an Immune Booster and their Therapeutic Option Against COVID-19.Natural products and bioprospecting · 2020Article
- Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections.Frontiers in immunology · 2020Review
- Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses.PloS one · 2017Article
- Cationic host defence peptides: potential as antiviral therapeutics.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2013Review
- Human coronavirus HKU1 infection of primary human type II alveolar epithelial cells: cytopathic effects and innate immune response.PloS one · 2013Article
- Virus-infected alveolar epithelial cells direct neutrophil chemotaxis and inhibit their apoptosis.American journal of respiratory cell and molecular biology · 2012Article
- Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts.Journal of affective disorders · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Viruses that infect the lung are a significant cause of morbidity and mortality in animals and humans worldwide. Coronaviruses are being associated increasingly with severe diseases in the lower respiratory tract. Alveolar epithelial cells are an important target for coronavirus infection in the lung, and infected cells can initiate innate immune responses to viral infection. In this overview, we describe in vitro models of highly differentiated alveolar epithelial cells that are currently being used to study the innate immune response to coronavirus infection. We have shown that rat coronavirus infection of rat alveolar type I epithelial cells in vitro induces expression of CXC chemokines, which may recruit and activate neutrophils. Although neutrophils are recruited early in infection in several coronavirus models including rat coronavirus. However, their role in viral clearance and/or immune-mediated tissue damage is not understood. Primary cultures of differentiated alveolar epithelial cells will be useful for identifying the interactions between coronaviruses and alveolar epithelial cells that influence the innate immune responses to infection in the lung. Understanding the molecular details of these interactions will be critical for the design of effective strategies to prevent and treat coronavirus infections in the lung.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.