ArticleThe Journal of biological chemistry2009
Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1).
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Blockade of the mineralocorticoid receptor improves markers of human endothelial cell dysfunction and hematological indices in a mouse model of sickle cell disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Trial
- Residual risk in cardiovascular and renal diseases and the potential role of aldosterone synthase inhibitors.Frontiers in cardiovascular medicine · 2026Review
- Endothelin-1 signaling in the kidney: recent advances and remaining gaps.American journal of physiology. Renal physiology · 2025Review
- Endothelin and the tumor microenvironment: a finger in every pie.Clinical science (London, England : 1979) · 2024Review
- Aldosterone: Renal Action and Physiological Effects.Comprehensive Physiology · 2023Article
- Circadian clocks of the kidney: function, mechanism, and regulation.Physiological reviews · 2022Review
- Integrated bioinformatic analysis reveals immune molecular markers and potential drugs for diabetic cardiomyopathy.Frontiers in endocrinology · 2022Article
- Circadian Control of Sodium and Blood Pressure Regulation.American journal of hypertension · 2021Review
- Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine.The EPMA journal · 2021Review
- In vivo assessment of a single adenine mutation in 5'UTR of Endothelin-1 gene in paediatric cases with severe pulmonary hypertension: an observational study.BMC research notes · 2021Observational
- Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.Canadian journal of physiology and pharmacology · 2020Article
- Circadian regulation of kidney function: finding a role for Bmal1.American journal of physiology. Renal physiology · 2018Review
- TSS-Seq analysis of low pH-induced gene expression in intercalated cells in the renal collecting duct.PloS one · 2017Article
- Aldosterone alters the chromatin structure of the murine endothelin-1 gene.Life sciences · 2016Article
- Let-7i-5p represses brite adipocyte function in mice and humans.Scientific reports · 2016Article
- Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1.American journal of physiology. Renal physiology · 2015Article
- The roles of oxidative stress, endoplasmic reticulum stress, and autophagy in aldosterone/mineralocorticoid receptor-induced podocyte injury.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.Life sciences · 2014Article
- MicroRNA regulation of endothelin-1 mRNA in renal collecting duct cells.Life sciences · 2014Article
- Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.American journal of physiology. Renal physiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Aldosterone and endothelin-1 (ET-1) act on collecting duct cells of the kidney and are important regulators of renal sodium transport and cardiovascular physiology. We recently identified the ET-1 gene (edn1) as a novel aldosterone-induced transcript. However, aldosterone action on edn1 has not been characterized at the present time. In this report, we show that aldosterone stimulated edn1 mRNA in acutely isolated rat inner medullary collecting duct cells ex vivo and ET-1 peptide in rat inner medulla in vivo. Aldosterone induction of edn1 mRNA occurred in cortical, outer medullary, and inner medullary collecting duct cells in vitro. Inspection of the edn1 promoter revealed two putative hormone response elements. Levels of heterogeneous nuclear RNA synthesis demonstrated that edn1 mRNA stimulation occurred at the level of transcription. RNA knockdowns corroborated pharmacological studies and demonstrated both mineralocorticoid receptor and glucocorticoid receptor participated in this response. Aldosterone resulted in dose-dependent nuclear translocation and binding of mineralocorticoid receptor and glucocorticoid receptor to the edn1 hormone response elements. Hormone receptors mediated the association of chromatin remodeling complexes, histone modification, and RNA polymerase II at the edn1 promoter. Direct interaction between aldosterone and ET-1 has important implications for renal and cardiovascular function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.