ArticleJournal of cardiothoracic surgery2009
Proanthocyanidin to prevent formation of the reexpansion pulmonary edema.
Article in Journal of cardiothoracic surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 13 citations in OpenAlex.
- A common gesture with a rare but potentially severe complication: Re-expansion pulmonary edema following chest tube drainage.Respiratory medicine case reports · 2019Article
- Investigation of the preventive effect of proanthocyanidin in ischemia-reperfusion injury in lung transplantation: An experimental study.Turk gogus kalp damar cerrahisi dergisi · 2018Article
- Reexpansion pulmonary edema after chest drainage for pneumothorax: A case report and literature overview.Respiratory medicine case reports · 2015Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to investigate the preventive effect of Proanthocyanidine (PC) in the prevention of RPE formation.
methodsSubjects were divided into four groups each containing 10 rats. In the Control Group (CG): RPE wasn't performed. Then subjects were followed up for three days and they were sacrificed after the follow up period. Samplings were made from tissues for measurement of biochemical and histopathologic parameters. In the Second Group (PCG): The same protocol as CG was applied, except the administration of PC to the subjects. In the third RPE Group (RPEG): Again the same protocol as CG was applied, but as a difference, RPE was performed. In the Treatment Group (TG): The same protocol as RPEG was applied except the administration of PC to the subjects.
resultsIn RPEG group, the most important histopathological finding was severe pulmonary edema with alveolar damage and acute inflammatory cells. These findings were less in the TG group. RPE caused increased MDA levels, and decreased GPx, SOD and CAT activity significantly in lung tissue.
conclusionPC decreased MDA levels. Oxidative stress plays an important role in pathophysiology of RPE and PC treatment was shown to be useful to prevent formation of RPE.
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Registered trials
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