ArticleHepatology (Baltimore, Md.)2009
Hepatic targeting and biodistribution of human fetal liver stem/progenitor cells and adult hepatocytes in mice.
Article in Hepatology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
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- Long-Term Management with Adipose Tissue-Derived Mesenchymal Stem Cells and Conventional Treatment in a Dog with Hepatocutaneous Syndrome.Journal of veterinary internal medicine · 2017Article
- Adult-Derived Human Liver Stem/Progenitor Cells Infused 3 Days Postsurgery Improve Liver Regeneration in a Mouse Model of Extended Hepatectomy.Cell transplantation · 2017Article
- Kupffer Cell Transplantation in Mice for Elucidating Monocyte/Macrophage Biology and for Potential in Cell or Gene Therapy.The American journal of pathology · 2016Article
- Hepatic stem cells: A viable approach for the treatment of liver cirrhosis.World journal of stem cells · 2015Review
- Noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2015Article
- EpCAM and the biology of hepatic stem/progenitor cells.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- Unbalanced distribution of materials: the art of giving rise to hepatocytes from liver stem/progenitor cells.Journal of cellular and molecular medicine · 2014Review
- The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells.Current topics in developmental biology · 2014Review
- Bone-derived mesenchymal stromal cells from HIV transgenic mice exhibit altered proliferation, differentiation capacity and paracrine functions along with impaired therapeutic potential in kidney injury.Experimental cell research · 2013Article
- Human Liver Progenitor Cells for Liver Repair.Cell medicine · 2013Review
- Transplantation of bone marrow-derived MSCs improves cisplatinum-induced renal injury through paracrine mechanisms.Experimental and molecular pathology · 2013Article
- Article
- Orthopaedic applications of nanoparticle-based stem cell therapies.Stem cell research & therapy · 2012Review
- Human hepatocyte transplantation: current experience and future challenges.Nature reviews. Gastroenterology & hepatology · 2010Review
- Hepatic differentiation of human pluripotent stem cells by developmental stage-related metabolomics products.Differentiation; research in biological diversityArticle
Corrections and comments
- Correction · 2015-02-13Concerns/Issues about Image · Investigation by Company/Institution · Objections by Third Party ·
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledTracking stem/progenitor cells through noninvasive imaging is a helpful means of assessing the targeting of transplanted cells to specific organs. We performed in vitro and in vivo studies wherein adult human hepatocytes and human fetal liver stem/progenitor cells were labeled with indium-111 ((111)In)-oxine and technetium-99m ((99m)Tc)-Ultratag or (99m)Tc-Ceretec. The labeling efficiency and viability of cells was analyzed in vitro, and organ biodistribution of cells was analyzed in vivo after transplantation in xenotolerant nonobese diabetic/severe combined immunodeficiency mice through intrasplenic or intraportal routes. We found that adult hepatocytes and fetal liver stem/progenitor cells incorporated (111)In but not (99m)Tc labels. After radiolabeling, cell viability was unchanged. Transplanted adult hepatocytes or fetal liver stem/progenitor cells were targeted to the liver more effectively by the intraportal rather than the intrasplenic route. Transplanted cells were retained in the liver after intraportal injection and in the liver and spleen after intrasplenic injection, without translocations into pulmonary or systemic circulations. Compared with fetal liver stem/progenitor cells, fewer adult hepatocytes were retained in the spleen after intrasplenic transplantation. The distribution of transplanted cells in organs was substantiated by genetic assays, including polymerase chain reaction amplification of DNA sequences from a primate-specific Charcot-Marie-Tooth element, and in situ hybridization for primate alphoid satellite sequences ubiquitous in all centromeres.
conclusion(111)In labeling of human fetal liver stem/progenitor cells and adult hepatocytes was effective for noninvasive localization of transplanted cells. This should facilitate continued development of cell therapies through further animal and clinical studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.