ArticleClinical and experimental nephrology2009
Histopathological spectrum of childhood nephrotic syndrome in Pakistan.
Article in Clinical and experimental nephrology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 54 citations in OpenAlex.
- Incidence and Pathological Patterns of Nephrotic Syndrome among Infants and Children: A Systematic Review.Cureus · 2024Review
- Clinical Characteristics, Pathological Features and Treatment Outcomes of Children With Nephrotic Syndrome at Princess Marina Hospital, Botswana.Global pediatric health · 2024Article
- Screening of theFrontiers in genetics · 2018Article
- Article
- Pediatric Renal Biopsies in India: A Single-Centre Experience of Six Years.Nephro-urology monthly · 2015Article
- Spectrum of steroid-resistant and congenital nephrotic syndrome in children: the PodoNet registry cohort.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Pathological profile of biopsied Egyptian children with primary nephrotic syndrome: 15-year single center experience.Journal of nephrology · 2014Article
- Frequency and clinicopathological correlations of histopathological variants of pediatric idiopathic focal segmental glomerulosclerosis.Indian journal of nephrology · 2014Article
- Unanswered questions in childhood idiopathic nephrotic syndrome.Journal of renal injury prevention · 2014Article
- IgM nephropathy; can we still ignore it.Journal of nephropathology · 2013Review
- R: Histological patterns of idiopathic steroid resistant nephrotic syndrome in Egyptian children: A single centre study.Journal of nephropathology · 2013Article
- The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome.BMC nephrology · 2013Article
- Detection of immunoglobulins and complement components in formalin fixed and paraffin embedded renal biopsy material by immunoflourescence technique.Journal of nephropathology · 2012Article
- Journal of Nephropathology: A need of the hour.Journal of nephropathology · 2012Article
- The spectrum of histopathological lesions in children presenting with steroid-resistant nephrotic syndrome at a single center in Pakistan.TheScientificWorldJournal · 2012Article
- Comment on "Ten-year experience of pediatric renal biopsies from a single center in Pakistan".Indian journal of nephrology · 2012Article
- An estimation of steroid responsiveness of idiopathic nephrotic syndrome in Iranian children.Iranian journal of pediatrics · 2010Article
- Frequency of kidney diseases and clinical indications of pediatric renal biopsy: A single center experience.Indian journal of nephrologyArticle
- A histopathological outlook on nephrotic syndrome: A pediatric perspective.Indian journal of nephrologyArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is no information in international literature on the pattern of glomerulopathies in children with idiopathic nephrotic syndrome (INS) in Pakistan. We undertook this study to determine the pattern of glomerulopathies based on renal biopsies studied by light (LM), immunofluorescence (IF), and electron microscopy (EM).
methodsThe study was conducted at Sindh Institute of Urology and Transplantation (SIUT), Karachi over 12 years (1996-2008). All children (<or=18 years) with INS in whom renal biopsy was performed were included. Renal biopsies were studied by LM, IF, and EM.
resultsOf 538 children, 347 (64.4%) were male and 191 (35.5%) were female. Mean age was 9.79 +/- 4.59 years. The histopathological lesions comprised: minimal change disease (MCD) and its variants, 43.8%; focal segmental glomerulosclerosis (FSGS), 38.14%; membranous glomerulonephritis (GN) (MGN), 7.96%; mesangioproliferative GN (MesPGN), 4.81%; mesangiocapillary GN (MPGN), 3.14%; IgA nephropathy (IgAN), 1.11%; and other rare lesions.
conclusionMCD and its variants are the leading cause of overall INS in children, followed by FSGS, which is the predominant pathology in steroid-resistant and adolescent nephrotic syndrome (NS). Our data are in accordance with recent series from around the world with similar biopsy indications. The study defines the true pattern of glomerulopathies in childhood INS for the first time in Pakistan.
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