ArticleKlinische Neuroradiologie2009
Linear longitudinal decline in fractional anisotropy in patients with amyotrophic lateral sclerosis: preliminary results.
Article in Klinische Neuroradiologie, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The value of magnetic resonance imaging as a biomarker for amyotrophic lateral sclerosis: a systematic review.BMC neurology · 2016Pooled it
- Brain diffusion tensor imaging in dogs with degenerative myelopathy.Journal of veterinary internal medicine · 2021Article
- Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis.BMC medical imaging · 2020Article
- Investigation of Neurodegenerative Processes in Amyotrophic Lateral Sclerosis Using White Matter Fiber Density.Clinical neuroradiology · 2019Article
- Tract integrity in amyotrophic lateral sclerosis: 6-month evaluation using MR diffusion tensor imaging.BMC medical imaging · 2019Article
- Rapid myelin water imaging for the assessment of cervical spinal cord myelin damage.NeuroImage. Clinical · 2019Article
- Imaging Biomarkers for the Diagnosis and Prognosis of Neurodegenerative Diseases. The Example of Amyotrophic Lateral Sclerosis.Frontiers in neuroscience · 2018Review
- Dynamic changes in diffusion measures improve sensitivity in identifying patients with mild traumatic brain injury.PloS one · 2017Article
- Use of diffusion spectrum imaging in preliminary longitudinal evaluation of amyotrophic lateral sclerosis: development of an imaging biomarker.Frontiers in human neuroscience · 2014Article
- Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosis.BMC neuroscience · 2012Article
- Structural imaging differences and longitudinal changes in primary lateral sclerosis and amyotrophic lateral sclerosis.NeuroImage. Clinical · 2012Article
- Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study.Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases · 2011Article
- White matter alterations differ in primary lateral sclerosis and amyotrophic lateral sclerosis.Brain : a journal of neurology · 2011Article
- The application of biomarkers in clinical trials for motor neuron disease.Biomarkers in medicine · 2010Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAs potential therapies aimed at halting or slowing the decline in upper motor neuron function in patients with amyotrophic lateral sclerosis (ALS) or primary lateral sclerosis (PLS) are developed, a quantitative method for monitoring response will be necessary. Measurement of fractional anisotropy (FA) using diffusion tensor imaging (DTI) over time should parallel functional decline from upper motor neuron degeneration in these patients. PATIENTS AND
methodsTwo patients with definite ALS were imaged at 3.0 T and FA values were obtained in the corticospinal tract every 3 months for 1 year. The FA values were compared to normal age-matched controls.
resultsBoth patients showed linear decreases in FA values over time with R(2) values ranging from 0.93 to 0.99. The decline became statistically significant over the course of the study. Qualitative decreases in anisotropy were also evident on FA maps.
conclusionIf these trends can be validated in greater numbers of patients, DTI may serve as an objective quantitative biomarker for disease progression in patients with upper motor neuron disease.
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