ArticleJournal of biomedicine & biotechnology2009
Epsilon haemoglobin specific antibodies with applications in noninvasive prenatal diagnosis.
Article in Journal of biomedicine & biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Isolation and Enrichment of Circulating Fetal Cells for NIPD: An Overview.Diagnostics (Basel, Switzerland) · 2021Review
- Article
- Exploring early human brain development with structural and physiological neuroimaging.NeuroImage · 2019Review
- Upregulation of Mrps18a in breast cancer identified by selecting phage antibody libraries on breast tissue sections.BMC cancer · 2017Article
- Noninvasive prenatal diagnosis of fetal aneuploidy by circulating fetal nucleated red blood cells and extravillous trophoblasts using silicon-based nanostructured microfluidics.Molecular cytogenetics · 2017Article
- Selection of a breast cancer subpopulation-specific antibody using phage display on tissue sections.Immunologic research · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasive procedures for prenatal diagnosis are associated with increased risk of abortion; thus, development of noninvasive procedures would be beneficial. Based on the observation that embryonic nucleated red blood cell (NRBC) crosses the placenta and enters the circulation of pregnant women, the ability to identify such cell would allow development of such procedures. Identification of NRBCs in blood samples would be possible provided that specific antibodies are available. Here we have isolated recombinant antibodies using phage display. From the panel of antibody fragments specifically recognising epsilon-Hb, one was chosen for further characterization, DAb1. DAb1 binds to epsilon-Hb both in Western blots and immunocytochemistry. Several epsilon-Hb positive cells were detected in a blood sample taken as postchorionic villus sampling (CVS). To evaluate the sensitivity of the method, K562 cells (which express epsilon-Hb) were spiked in a blood sample followed by staining in solution and FACS analysis.
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Registered trials
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