ArticlePloS one2009
Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association.Scientific reports · 2017Pooled it
- The intersection of mitochondria, lipids, and ferroptosis: a new avenue for dry age-related macular degeneration.Apoptosis : an international journal on programmed cell death · 2025Review
- Female-specific association among I, J and K mitochondrial genetic haplogroups and cancer: A longitudinal cohort study.Cancer genetics · 2018Article
- Mitochondrial genome variation and prostate cancer: a review of the mutational landscape and application to clinical management.Oncotarget · 2017Review
- Mitochondrial Haplogroup T Is Associated with Obesity in Austrian Juveniles and Adults.PloS one · 2015Article
- Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions.Human molecular genetics · 2014Article
- No association between typical European mitochondrial variation and prostate cancer risk in a Spanish cohort.Journal of human genetics · 2014Article
- Mitochondrial DNA haplogroups and susceptibility to prostate cancer in a colombian population.ISRN oncology · 2014Article
- The awakening of an advanced malignant cancer: an insult to the mitochondrial genome.Biochimica et biophysica acta · 2012Review
- Sequence-based polymorphisms in the mitochondrial D-loop and potential SNP predictors for chronic dialysis.PloS one · 2012Article
- Mitochondrial haplogroups and control region polymorphisms in age-related macular degeneration: a case-control study.PloS one · 2012Article
- Mitochondrial haplogroups and polymorphisms reveal no association with sporadic prostate cancer in a southern European population.PloS one · 2012Article
- The role of the mitochondrial genome in ageing and carcinogenesis.Journal of aging research · 2011Article
- The mitochondrial T16189C polymorphism is associated with coronary artery disease in Middle European populations.PloS one · 2011Article
- Mitochondrial haplogroups, control region polymorphisms and malignant melanoma: a study in middle European Caucasians.PloS one · 2011Article
- Somatic mutations throughout the entire mitochondrial genome are associated with elevated PSA levels in prostate cancer patients.American journal of human genetics · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBesides being responsible for energy production in the cell, mitochondria are central players in apoptosis as well as the main source of harmful reactive oxygen species. Therefore, it can be hypothesised that sequence variation in the mitochondrial genome is a contributing factor to the etiology of diseases related to these different cellular events, including cancer. The aim of the present study was to assess the frequency of haplogroups and polymorphisms in the control region (CR) of mitochondrial DNA of peripheral blood mononuclear cells from patients with prostate carcinoma (n = 304) versus patients screened for prostate disease but found to be negative for cancer on biopsy (n = 278) in a Middle European population. METHODOLOGY/PRINCIPAL
findingsThe nine major European haplogroups and the CR polymorphisms were identified by means of primer extension analysis and DNA sequencing, respectively. We found that mitochondrial haplogroup frequencies and CR polymorphisms do not differ significantly between patients with or without prostate cancer, implying no impact of inherited mitochondrial DNA variation on predisposition to prostate carcinoma in a Middle European population. CONCLUSIONS/SIGNIFICANCE: Our results contrast with a recent report claiming an association between mtDNA haplogroup U and prostate cancer in a North American population of caucasian descent.
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