ArticleFrontiers in human neuroscience2009
Why do delusions persist?
Article in Frontiers in human neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 145 citations in OpenAlex.
- Internal monitoring deficits attenuate post-error slowing in psychosis-proneness.Schizophrenia research. Cognition · 2026Article
- A review and integration of models on delusion maintenance.Psychological medicine · 2026Review
- The Relationship Between Schizotypy and Latent Inhibition and Conditioned Inhibition.Schizophrenia bulletin open · 2026Article
- Delusional Unreality and Predictive Processing.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Belief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders.Schizophrenia bulletin · 2025Article
- Spurious autobiographical memories of psychosis: a dopamine-gated neuroplasticity account for relapse and treatment-resistant psychosis.Psychological medicine · 2025Review
- Aberrant salience signaling in auditory processing in schizophrenia: Evidence for abnormalities in both sensory processing and emotional reactivity.Schizophrenia research · 2024Article
- Effectiveness and cost-effectiveness of online recorded recovery narratives in improving quality of life for people with psychosis experience (NEON Trial): a pragmatic randomised controlled trial.The Lancet regional health. Europe · 2024Article
- Aberrant salience in acute versus chronic schizophrenia: Do medication and positive symptoms make a difference?Indian journal of psychiatry · 2024Article
- Case Files of the Emory University Medical Toxicology Fellowship: A Patient Presents to the Outpatient Toxicology Clinic with Delusions of Being Poisoned.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2024Article
- Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia.Frontiers in cellular neuroscience · 2023Article
- Rethinking delusions: A selective review of delusion research through a computational lens.Schizophrenia research · 2022Review
- Differences between delusional disorder and schizophrenia: A mini narrative review.World journal of psychiatry · 2022Review
- The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder.Current addiction reports · 2022Review
- Resistance to Extinction of Evaluative Fear Conditioning in Delusion Proneness.Schizophrenia bulletin open · 2022Article
- Models of Dynamic Belief Updating in Psychosis-A Review Across Different Computational Approaches.Frontiers in psychiatry · 2022Review
- Cognitive effects of rapid-acting treatments for resistant depression: Just adverse, or contributing to clinical efficacy?Journal of psychiatric research · 2021Review
- Enhancing Psychosis Risk Prediction Through Computational Cognitive Neuroscience.Schizophrenia bulletin · 2020Article
- Hallucinations in posttraumatic stress disorder: Insights from predictive coding.Journal of abnormal psychology · 2020Review
- Dopamine and glutamate in schizophrenia: biology, symptoms and treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Delusions are bizarre and distressing beliefs that characterize certain mental illnesses. They arise without clear reasons and are remarkably persistent. Recent models of delusions, drawing on a neuroscientific understanding of learning, focus on how delusions might emerge from abnormal experience. We believe that these models can be extended to help us understand why delusions persist. We consider prediction error, the mismatch between expectancy and experience, to be central. Surprising events demand a change in our expectancies. This involves making what we have learned labile, updating and binding the memory anew: a process of memory reconsolidation. We argue that, under the influence of excessive prediction error, delusional beliefs are repeatedly reconsolidated, strengthening them so that they persist, apparently impervious to contradiction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.