ArticlePLoS biology2009
Aneuploidy and improved growth are coincident but not causal in a yeast cancer model.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Loss of G1-phase CDK-inhibition biases instability between genomic regions by unevenly reducing activity among replication origins.iScience · 2025Article
- Four decades of Eukaryotic DNA replication: From yeast genetics to high-resolution cryo-EM structures of the replisome.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Fermentative metabolism impedes p53-dependent apoptosis in a Crabtree-positive but not in Crabtree-negative yeast.Journal of biosciences · 2017Article
- Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation.PLoS genetics · 2016Article
- Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.Molecular and cellular biology · 2015Article
- Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver.Genetics · 2012Article
- Genome rearrangements caused by depletion of essential DNA replication proteins in Saccharomyces cerevisiae.Genetics · 2012Article
- Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells.Nucleic acids research · 2012Article
- MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.The Journal of clinical investigation · 2012Article
- A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis.PLoS genetics · 2012Article
- How dormant origins promote complete genome replication.Trends in biochemical sciences · 2011Review
- Ploidy influences cellular responses to gross chromosomal rearrangements in Saccharomyces cerevisiae.BMC genomics · 2011Article
- Article
- Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.Molecular cell · 2011Article
- Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.PLoS genetics · 2010Article
- Aneuploid chromosomes are highly unstable during DNA transformation of Candida albicans.Eukaryotic cell · 2009Article
- Roles of DNA helicases in the maintenance of genome integrity.Molecular & cellular oncologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cancer cells have acquired mutations that alter their growth. Aneuploidy that typify cancer cells are often assumed to contribute to the abnormal growth characteristics. Here we test the idea of a link between aneuploidy and mutations allowing improved growth, using Saccharomyces cerevisiae containing a mcm4 helicase allele that was shown to cause cancer in mice. Yeast bearing this mcm4 allele are prone to undergoing a "hypermutable phase" characterized by a changing karyotype, ultimately yielding progeny with improved growth properties. When such progeny are returned to a normal karyotype by mating, their improved growth remains. Genetic analysis shows their improved growth is due to mutations in just a few loci. In sum, the effects of the mcm4 allele in mice are recapitulated in yeast, and the aneuploidy is not required to maintain improved growth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.