ArticleJournal of endocrinological investigation2009
Papillary thyroid cancer, although strongly associated with lymphocytic infiltration on histology, is only weakly predicted by serum thyroid auto-antibodies in patients with nodular thyroid diseases.
Article in Journal of endocrinological investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Geographic variation in the association between Hashimoto's thyroiditis and Papillary thyroid carcinoma, a meta-analysis.Endocrine · 2023Pooled it
- Classification of Thyroid Nodules with Stacked Denoising Sparse Autoencoder.International journal of endocrinology · 2020Article
- Thyroid Carcinoma Coexisting with Hashimoto's Thyreoiditis: Clinicopathological and Molecular Characteristics Clue up Pathogenesis.Pathology oncology research : POR · 2019Article
- Influence of Hashimoto Thyroiditis on the Development of Thyroid Nodules and Cancer in Children and Adolescents.Journal of the Endocrine Society · 2019Article
- Gender-specific correlation of intranodular chronic lymphocytic thyroiditis with thyroid nodule size, echogenicity, and histologically-verified cytological class of malignancy risk.Journal of clinical & translational endocrinology · 2018Article
- High prevalence of papillary thyroid carcinoma in nodular Hashimoto's thyroiditis at the first diagnosis and during the follow-up.Journal of endocrinological investigation · 2018Article
- Concomitant papillary thyroid carcinoma and mucosa-associated lymphoid tissue thyroid lymphoma in the setting of Hashimoto thyroiditis.International journal of clinical and experimental pathology · 2018Article
- Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study.International journal of endocrinology · 2018Article
- Thyroid autoimmunity: is really associated with papillary thyroid carcinoma?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
- Thyroid functional parameters and correlative autoantibodies as prognostic factors for differentiated thyroid cancers.Oncotarget · 2016Article
- Article
- Iodine, thyroid autoimmunity and cancer.European thyroid journal · 2015Article
- Peroxisome Proliferator-Activated Receptor- γ in Thyroid Autoimmunity.PPAR research · 2015Review
- Biomarkers of thyroid function and autoimmunity for predicting high-risk groups of thyroid cancer: a nested case-control study.BMC cancer · 2014Article
- Papillary Thyroid Cancer and Hashimoto's Thyroiditis: An Association Less Understood.Indian journal of surgical oncology · 2014Review
- Article
- Hashimoto's thyroiditis pathology and risk for thyroid cancer.Thyroid : official journal of the American Thyroid Association · 2014Article
- Both thyroid autoimmunity and increased serum TSH are independent risk factors for malignancy in patients with thyroid nodules.Journal of endocrinological investigation · 2013Article
- Serum 8-OHdG and HIF-1α levels: do they affect the development of malignancy in patients with hypoactive thyroid nodules?Contemporary oncology (Poznan, Poland) · 2013Article
- Clinical and pathological implications of concurrent autoimmune thyroid disorders and papillary thyroid cancer.Journal of thyroid research · 2011Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe evaluated the association between thyroid autoimmunity and thyroid cancer in a retrospective series of unselected thyroid nodules submitted to fine-needle aspiration (FNA) cytology.
designAnti-thyroid antibodies (TAb) were measured in patients with multinodular goiter (MNG) and single/isolated thyroid nodule (S/I) submitted to FNA. Thyroid lymphocytic infiltration (LI) on histology was studied in a subgroup of patients submitted to thyroidectomy; 13,021 patients were included: on cytology 622 had papillary thyroid cancer (c- PTC) and 12,399 benign thyroid nodular diseases (c-BTN). LI was evaluated in histological samples of 688 patients: 304 with PTC (h-PTC) and 384 with BTN (h-BTN).
resultsTAb prevalence was not different in c-BTN and c-PTC (38.7% vs 35.6%). TAb were more frequent in c-BTN than c-PTC in females with MNG (40.1% vs 32.5%, p=0.02), and in c-PTC than in c-BTN in males with S/I (31.2% vs 20.4%, p=0.02) and, although not significantly, in females younger than 30 yr (35.1% vs 30.7%). The frequency and severity of LI was significantly higher in h-PTC than h-BTN, both in MNG (82.5% vs 45.0%, p<0.001) and S/I (85.6% vs 71.0%, p<0.001), but a higher number of patients with h-PTC had negative circulating TAb, despite the presence of moderate/severe LI.
conclusionsTAb are weakly associated to PTC in males and young females, while they are more frequent in older females with BTN. The frequency and severity of LI is significantly higher in PTC than in BTN, but in cancer patients TAb are frequently negative, despite the evidence of histological thyroiditis. These data suggest that different kinds of immune response may be involved in PTC and BTN.
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