Evidence map›Paper›PMID 19636082›Full record

ArticlePhysics in medicine and biology2009

Optical imaging of Cerenkov light generation from positron-emitting radiotracers.

R Robertson, M S Germanos, C Li, G S Mitchell, S R Cherry, M D Silva

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Article
  4. Review
  5. Advanced Image-Guidance and Surgical-Navigation Techniques for Real-Time Visualized Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Article
  7. Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  8. Article
  9. Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging.European journal of nuclear medicine and molecular imaging · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Observational
  19. Article
  20. Article

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R RobertsonDepartment of Imaging Sciences, Millennium Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
M S Germanos
C Li
G S Mitchell
S R Cherry
M D Silva

Funding

UC Davis Mouse Cancer Imaging ProgramU24CA110804 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHERRY, SIMON R · 2007 to 2008
$1.2M
Hyperspectral Optical Tomography for Molecular ImagingR01CA121783 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHERRY, SIMON R · 2006 to 2009
$1.2M
NCI NIH HHS R01 CA121783NCI NIH HHS U24 CA110804
6 · The paper itself

Abstract

Radiotracers labeled with high-energy positron emitters, such as those commonly used for positron emission tomography studies, emit visible light immediately following decay in a medium. This phenomenon, not previously described for these imaging tracers, is consistent with Cerenkov radiation and has several potential applications, especially for in vivo molecular imaging studies. Herein we detail a new molecular imaging tool, Cerenkov Luminescence Imaging, the experiments conducted that support our interpretation of the source of the signal, and proof-of-concept in vivo studies that set the foundation for future application of this new method.

Indexed as

ElectronsLightAnimalsColonic NeoplasmsFluorodeoxyglucose F18HumansLuminescent MeasurementsMicePositron-Emission TomographyRadioactive TracersUltraviolet RaysFluorodeoxyglucose F18Radioactive Tracers

Identifiers

PMID19636082
PMCPMC2765256

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.