ArticleBlood2009
A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients.
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Molecular Biomarkers in Prediction of High-Grade Transformation and Outcome in Patients with Follicular Lymphoma: A Comprehensive Systemic Review.International journal of molecular sciences · 2024Pooled it
- Repression of miR-29 via MYC leads to increased CD40 signaling in transformed follicular lymphoma.Leukemia · 2026Trial
- A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy.Haematologica · 2019Trial
- LAP2α drives breast tumorigenesis by mitigating replication stress.Cell death & disease · 2026Article
- Impact of the Immune Landscape in Follicular Lymphoma: Insights into Histological Transformation in the Rituximab Era.Cancers · 2024Article
- Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma.Blood cancer journal · 2024Article
- Follicular lymphoma with Epstein-Barr virus-associated transformation: A case report and review of the literature.Journal of clinical and experimental hematopathology : JCEH · 2024Review
- NMR-based metabolomic profiling can differentiate follicular lymphoma from benign lymph node tissues and may be predictive of outcome.Scientific reports · 2022Article
- Unveiling the Role of the Tumor Microenvironment in the Treatment of Follicular Lymphoma.Cancers · 2022Review
- A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk.Genome biology · 2020Article
- A modular transcriptome map of mature B cell lymphomas.Genome medicine · 2019Article
- Clinicopathologic and Prognostic Significance of Thymopoietin-α Overexpression in Gastric Cancer.Journal of Cancer · 2019Article
- Systematic analysis of the frequently amplified 2p15-p16.1 locus reveals PAPOLG as a potential proto-oncogene in follicular and transformed follicular lymphoma.Turkish journal of biology = Turk biyoloji dergisi · 2019Article
- A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a retrospective training and validation analysis in three international cohorts.The Lancet. Oncology · 2018Article
- From genetics to the clinic: a translational perspective on follicular lymphoma.Nature reviews. Cancer · 2018Review
- A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia.Nature communications · 2018Article
- Article
- Extracting a low-dimensional description of multiple gene expression datasets reveals a potential driver for tumor-associated stroma in ovarian cancer.Genome medicine · 2016Article
- Identifying Network Perturbation in Cancer.PLoS computational biology · 2016Article
- Sparse expression bases in cancer reveal tumor drivers.Nucleic acids research · 2015Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Histologic transformation (HT) of follicular lymphoma to diffuse large B-cell lymphoma (DLBCL-t) is associated with accelerated disease course and drastically worse outcome, yet the underlying mechanisms are poorly understood. We show that a network of gene transcriptional modules underlies HT. Central to the network hierarchy is a signature strikingly enriched for pluripotency-related genes. These genes are typically expressed in embryonic stem cells (ESCs), including MYC and its direct targets. This core ESC-like program was independent of proliferation/cell-cycle and overlapped but was distinct from normal B-cell transcriptional programs. Furthermore, we show that the ESC program is correlated with transcriptional programs maintaining tumor phenotype in transgenic MYC-driven mouse models of lymphoma. Although our approach was to identify HT mechanisms rather than to derive an optimal survival predictor, a model based on ESC/differentiation programs stratified patient outcomes in 2 independent patient cohorts and was predictive of propensity of follicular lymphoma tumors to transform. Transformation was associated with an expression signature combining high expression of ESC transcriptional programs with reduced expression of stromal programs. Together, these findings suggest a central role for an ESC-like signature in the mechanism of HT and provide new clues for potential therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.