Trial reportNeurology2009
Effects of active HCV replication on neurologic status in HIV RNA virally suppressed patients.
Trial report in Neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Neurocognitive Functions in Patients with Comorbid Hepatitis C and Opioid Dependence: A Comparative Study.Indian journal of psychological medicine · 2023Article
- Declining Prevalence of Human Immunodeficiency Virus (HIV)-Associated Neurocognitive Disorders in Recent Years and Associated Factors in a Large Cohort of Antiretroviral Therapy-Treated Individuals With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Neurocognitive Trajectories After 72 Weeks of First-Line Anti-retroviral Therapy in Vietnamese Adults With HIV-HCV Co-infection.Frontiers in neurology · 2021Article
- Hepatitis C Virus Cure in Human Immunodeficiency Virus Coinfection Dampens Inflammation and Improves Cognition Through Multiple Mechanisms.The Journal of infectious diseases · 2020Article
- Hepatitis C virus-related factors associated WITH cognitive performance in HIV-HCV-coinfected patients.Journal of neurovirology · 2019Article
- Psychosocial and Neurocognitive Factors Associated With Hepatitis C - Implications for Future Health and Wellbeing.Frontiers in psychology · 2018Review
- Improvements in brain and behavior following eradication of hepatitis C.Journal of neurovirology · 2017Article
- Liver Fibrosis Linked to Cognitive Performance in HIV and Hepatitis C.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- The impact of human immune deficiency virus and hepatitis C coinfection on white matter microstructural integrity.Journal of neurovirology · 2016Article
- Chronic inflammation and the role for cofactors (hepatitis C, drug abuse, antiretroviral drug toxicity, aging) in HAND persistence.Current HIV/AIDS reports · 2014Review
- Peripheral neuropathy in ART-experienced patients: prevalence and risk factors.Journal of neurovirology · 2013Article
- Neurological Complications in Controlled HIV Infection.Current infectious disease reports · 2013Article
- Article
- Neurological complications of hepatitis C infection.Current neurology and neuroscience reports · 2012Review
- HIV-associated sensory neuropathy: risk factors and genetics.Current pain and headache reports · 2012Review
- Effects of hepatitis C and HIV on cognition in women: data from the Women's Interagency HIV Study.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Neurocognitive effects of HIV, hepatitis C, and substance use history.Journal of the International Neuropsychological Society : JINS · 2012Article
- Plasma sCD14 is a biomarker associated with impaired neurocognitive test performance in attention and learning domains in HIV infection.Journal of acquired immune deficiency syndromes (1999) · 2011Article
- Fulminant encephalopathy with basal ganglia hyperintensities in HIV-infected drug users.Neurology · 2011Article
- HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies.Current HIV/AIDS reports · 2011Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundHepatitis C virus (HCV) is a frequent copathogen with HIV. Both viruses appear to replicate in the brain and both are implicated in neurocognitive and peripheral neuropathy syndromes. Interaction of the viruses is likely to be complicated and better understanding of the contributions of each virus will be necessary to make evidence-based therapeutic decisions.
methodsThis study was designed to determine if active HCV infection, identified by quantitative HCV RNA determination, is associated with increased neurocognitive deficits or excess development of distal sensory peripheral neuropathy in HIV coinfected patients with stable HIV viral suppression. The AIDS Clinical Trials Group Longitudinal Linked Randomized Trials (ALLRT) study was the source of subjects with known HIV treatment status, neurocognitive and neuropathy evaluations, and HCV status. Subjects were selected based on HCV antibody status (249 positive; 310 negative).
resultsHCV RNA viral loads were detectable in 172 participants with controlled HIV infection and available neurologic evaluations in the ALLRT. These participants were compared with 345 participants with undetectable HCV viral load and the same inclusion criteria from the same cohort. Neurocognitive performance measured by Trail-Making A or B and digit symbol testing was not dissimilar between the 2 groups. In addition, there was no significant association between active HCV replication and distal sensory neuropathy.
conclusionClinically significant neurocognitive dysfunction and peripheral neuropathy were not exacerbated by active hepatitis C virus infection in the setting of optimally treated HIV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.