ArticleCirculation2009
Termination of atrial fibrillation using pulsed low-energy far-field stimulation.
Article in Circulation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 180 citations in OpenAlex.
- Towards Low Energy Atrial Defibrillation.Sensors (Basel, Switzerland) · 2015Trial
- Low-intensity shockwave therapy in men's health: Insights from a systematic review on erectile dysfunction and CP/CPPS in the Middle East.Arab journal of urology · 2026Review
- Success rates of simulated multi-pulse defibrillation protocols are sensitive to application timing with individual, protocol-specific optimal timings.Frontiers in network physiology · 2025Article
- Fast interactive simulations of cardiac electrical activity in anatomically accurate heart structures by compressing sparse uniform cartesian grids.Computer methods and programs in biomedicine · 2024Article
- Experimental studies of spiral wave teleportation in a light sensitive Belousov-Zhabotinsky system.Chaos (Woodbury, N.Y.) · 2024Article
- A cross species thermoelectric and spatiotemporal analysis of alternans in live explanted hearts using dual voltage-calcium fluorescence optical mapping.Physiological measurement · 2024Article
- Chaos control in cardiac dynamics: terminating chaotic states with local minima pacing.Frontiers in network physiology · 2024Article
- In silico optical modulation of spiral wave trajectories in cardiac tissue.Pflugers Archiv : European journal of physiology · 2023Article
- Dissolution of spiral wave's core using cardiac optogenetics.PLoS computational biology · 2023Article
- Electrical Stimulation for Low-Energy Termination of Cardiac Arrhythmias: a Review.Cardiovascular drugs and therapy · 2023Review
- Optical mapping of contracting hearts.The Journal of physiology · 2023Review
- Optimising low-energy defibrillation in 2D cardiac tissue with a genetic algorithm.Frontiers in network physiology · 2023Article
- The physics of heart rhythm disorders.Physics reports · 2022Article
- Non-monotonous dose response function of the termination of spiral wave chaos.Scientific reports · 2022Article
- Terminating spiral waves with a single designed stimulus: Teleportation as the mechanism for defibrillation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Optical Ultrastructure of Large Mammalian Hearts Recovers Discordant Alternans byFrontiers in network physiology · 2022Article
- Intermittent trapping of spiral waves in a cardiac model.Physical review. E · 2022Article
- Article
- Personalized Low-Energy Defibrillation Through Feedback Based Resynchronization Therapy.Computing in cardiology · 2020Article
- In-silico study of the cardiac arrhythmogenic potential of biomaterial injection therapy.Scientific reports · 2020Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundElectrically based therapies for terminating atrial fibrillation (AF) currently fall into 2 categories: antitachycardia pacing and cardioversion. Antitachycardia pacing uses low-intensity pacing stimuli delivered via a single electrode and is effective for terminating slower tachycardias but is less effective for treating AF. In contrast, cardioversion uses a single high-voltage shock to terminate AF reliably, but the voltages required produce undesirable side effects, including tissue damage and pain. We propose a new method to terminate AF called far-field antifibrillation pacing, which delivers a short train of low-intensity electric pulses at the frequency of antitachycardia pacing but from field electrodes. Prior theoretical work has suggested that this approach can create a large number of activation sites ("virtual" electrodes) that emit propagating waves within the tissue without implanting physical electrodes and thereby may be more effective than point-source stimulation. METHODS AND
resultsUsing optical mapping in isolated perfused canine atrial preparations, we show that a series of pulses at low field strength (0.9 to 1.4 V/cm) is sufficient to entrain and subsequently extinguish AF with a success rate of 93% (69 of 74 trials in 8 preparations). We further demonstrate that the mechanism behind far-field antifibrillation pacing success is the generation of wave emission sites within the tissue by the applied electric field, which entrains the tissue as the field is pulsed.
conclusionsAF in our model can be terminated by far-field antifibrillation pacing with only 13% of the energy required for cardioversion. Further studies are needed to determine whether this marked reduction in energy can increase the effectiveness and safety of terminating atrial tachyarrhythmias clinically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.