ArticleGenetics2009
The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Petanin Potentiated JNK Phosphorylation to Negatively Regulate the ERK/CREB/MITF Signaling Pathway for Anti-Melanogenesis in Zebrafish.International journal of molecular sciences · 2024Article
- The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Open biology · 2023Article
- Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature.Acta ophthalmologica · 2022Article
- Characterization ofGenes · 2020Article
- The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function.Scientific reports · 2019Article
- MITF-the first 25 years.Genes & development · 2019Review
- Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus.BMC evolutionary biology · 2019Article
- A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITFPigment cell & melanoma research · 2019Article
- RNAi-mediatedJournal of genetics · 2018Article
- Genomic regions controlling shape variation in the first upper molar of the house mouse.eLife · 2017Article
- The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology.Laboratory investigation; a journal of technical methods and pathology · 2017Review
- Genetic variations associated with six-white-point coat pigmentation in Diannan small-ear pigs.Scientific reports · 2016Article
- Microphthalmia-associated transcription factor in melanoma development and MAP-kinase pathway targeted therapy.Pigment cell & melanoma research · 2015Review
- Evidence for an alternatively spliced MITF exon 2 variant.The Journal of investigative dermatology · 2014Article
- Coat color determination by miR-137 mediated down-regulation of microphthalmia-associated transcription factor in a mouse model.RNA (New York, N.Y.) · 2012Article
- Melanoma: from mutations to medicine.Genes & development · 2012Review
- In vivo role of alternative splicing and serine phosphorylation of the microphthalmia-associated transcription factor.Genetics · 2012Article
- C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation.PloS one · 2011Article
- The discovery of the microphthalmia locus and its gene, Mitf.Pigment cell & melanoma research · 2010Review
- MiTF links Erk1/2 kinase and p21 CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells.Molecular cancer · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
Abstract
The microphthalmia-associated transcription factor (Mitf) has emerged as an important model for gene regulation in eukaryotic organisms. In vertebrates, it regulates the development of several cell types including melanocytes and has also been shown to play an important role in melanoma. In vitro, the activity of MITF is regulated by multiple signaling pathways, including the KITL/KIT/B-Raf pathway, which results in phosphorylation of MITF on serine residues 73 and 409. However, the precise role of signaling to MITF in vivo remains largely unknown. Here, we use a BAC transgene rescue approach to introduce specific mutations in MITF to study the importance of specific phospho-acceptor sites and protein domains. We show that mice that carry a BAC transgene where single-amino-acid substitutions have been made in the Mitf gene rescue the phenotype of the loss-of-function mutations in Mitf. This may indicate that signaling from KIT to MITF affects other phospho-acceptor sites in MITF or that alternative sites can be phosphorylated when Ser73 and Ser409 have been mutated. Our results have implications for understanding signaling to transcription factors. Furthermore, as MITF and signaling mechanisms have been shown to play an important role in melanomas, our findings may lead to novel insights into this resilient disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.