Evidence map›Paper›PMID 19635887›Full record

ArticleThe American journal of tropical medicine and hygiene2009

High frequency of antimicrobial drug resistance of diarrheagenic Escherichia coli in infants in Peru.

Theresa J Ochoa, Joaquím Ruiz, Margarita Molina, Luis J Del Valle, Martha Vargas, Ana I Gil, Lucie Ecker, Francesca Barletta, Eric Hall, Thomas G Cleary and 1 more

Open access · greenAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Colonizing and Virulence Factors in Enterotoxigenic Escherichia coli from Peru.The American journal of tropical medicine and hygiene · 2023
    Article
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  10. Review
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  15. Molecular Epidemiology of EnteroaggregativeInternational journal of molecular sciences · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Theresa J OchoaInstituto de Medicina Tropical, Universidad Peruana Cayetano Heredia, Lima, Peru. theresa.j.ochoa@uth.tmc.edu
Joaquím Ruiz
Margarita Molina
Luis J Del Valle
Martha Vargas
Ana I Gil
Lucie Ecker
Francesca Barletta
Eric Hall
Thomas G Cleary
Claudio F Lanata
Universidad Peruana Cayetano Heredia · PE

Funding

Randomonized controlled trial-lactoferrin prevention of diarrhea in childrenR01HD051716 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CLEARY, THOMAS GEORGE · 2007 to 2010
$960k
Role of virulence heterogeneity in acute and presistent EPEC diarrheaK01TW007405 · FIC · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI OCHOA, THERESA J · 2006 to 2009
$433k
FIC NIH HHS K01 TW007405NICHD NIH HHS R01 HD051716NICHD NIH HHS R01-HD051716
6 · The paper itself

Abstract

In a prospective passive diarrhea surveillance cohort study of 1,034 infants of low socioeconomic communities in Lima, Peru, we determined the prevalence and antimicrobial drug susceptibility of the diarrheagenic Escherichia coli . The prevalence of diarrheagenic E. coli was 29% (161 of 557) in children with gastroenteritis and 30% (58 of 195) in the control group without diarrhea. The most common E. coli pathogens in diarrhea were enteroaggregative E. coli (EAEC) (14%), enteropathogenic E. coli (EPEC) (7%), diffusely adherent E. coli (DAEC) (4%), and enterotoxigenic E. coli (ETEC) (4%). Diarrheagenic E. coli as a group exhibited high levels of antimicrobial drug resistance in diarrheal cases to ampicillin (85%), cotrimoxazole (79%), tetracycline (65%), and nalidixic acid (28%). Among individual E. coli groups in patients with diarrhea, DAEC and EAEC exhibited significant higher frequencies of resistance to ampicillin, cotrimoxazole, tetracycline and nalidixic acid than EPEC and ETEC. Antimicrobial drug resistance to ampicillin and cotrimoxazole were more frequent in E. coli isolated from diarrheal samples than controls, which reflected greater antibiotic exposure in patients with gastroenteritis.

Indexed as

Drug Resistance, Multiple, BacterialAnti-Bacterial AgentsDiarrhea, InfantileEscherichia coliEscherichia coli InfectionsHumansInfantPeruPopulation SurveillancePrevalenceProspective StudiesAnti-Bacterial Agents

Identifiers

PMID19635887
PMCPMC2824507
OpenAlexW2112432314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.