ArticleThe Journal of general physiology2009
The principal neurons of the medial nucleus of the trapezoid body and NG2(+) glial cells receive coordinated excitatory synaptic input.
Article in The Journal of general physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 78 citations in OpenAlex.
- The Many Lives of an Oligodendrocyte Precursor Cell.Annual review of neuroscience · 2025Review
- β-carbolines that enhance GABAFrontiers in cellular neuroscience · 2024Article
- Characterization of a new mouse line triggering transient oligodendrocyte progenitor depletion.Scientific reports · 2023Article
- Modulation of potassium conductances optimizes fidelity of auditory information.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Recent Insights into the Functional Role of AMPA Receptors in the Oligodendrocyte Lineage Cells In Vivo.International journal of molecular sciences · 2023Review
- Long-term microglia depletion impairs synapse elimination and auditory brainstem function.Scientific reports · 2022Article
- Synapse Maturation and Developmental Impairment in the Medial Nucleus of the Trapezoid Body.Frontiers in integrative neuroscience · 2022Review
- The bright and the dark side of myelin plasticity: Neuron-glial interactions in health and disease.Seminars in cell & developmental biology · 2021Article
- Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair.Frontiers in cell and developmental biology · 2021Review
- Approaches to Study Gap Junctional Coupling.Frontiers in cellular neuroscience · 2021Review
- Differential Modulators of NG2-Glia Differentiation into Neurons and Glia and Their Crosstalk.Cellular and molecular neurobiology · 2021Review
- Auditory brainstem development and plasticity.Current opinion in physiology · 2020Article
- The roles of neuron-NG2 glia synapses in promoting oligodendrocyte development and remyelination.Cell and tissue research · 2020Review
- Article
- A Vector-Based Method to Analyze the Topography of Glial Networks.International journal of molecular sciences · 2019Article
- Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis.Annual review of neuroscience · 2018Review
- Expression of functional inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 by astrocytes of inferior colliculus and hippocampus.Molecular brain · 2018Article
- Anisotropic Panglial Coupling Reflects Tonotopic Organization in the Inferior Colliculus.Frontiers in cellular neuroscience · 2018Article
- Structural Properties of Synaptic Transmission and Temporal Dynamics at Excitatory Layer 5B Synapses in the Adult Rat Somatosensory Cortex.Frontiers in synaptic neuroscience · 2018Article
- Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation.Nature communications · 2017Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glial cell processes are part of the synaptic structure and sense spillover of transmitter, while some glial cells can even receive direct synaptic input. Here, we report that a defined type of glial cell in the medial nucleus of the trapezoid body (MNTB) receives excitatory glutamatergic synaptic input from the calyx of Held (CoH). This giant glutamatergic terminal forms an axosomatic synapse with a single principal neuron located in the MNTB. The NG2 glia, as postsynaptic principal neurons, establish synapse-like structures with the CoH terminal. In contrast to the principal neurons, which are known to receive excitatory as well as inhibitory inputs, the NG2 glia receive mostly, if not exclusively, alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor-mediated evoked and spontaneous synaptic input. Simultaneous recordings from neurons and NG2 glia indicate that they partially receive synchronized spontaneous input. This shows that an NG2(+) glial cell and a postsynaptic neuron share presynaptic terminals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.