ArticleThe Journal of cell biology2009
A ZYG-12-dynein interaction at the nuclear envelope defines cytoskeletal architecture in the C. elegans gonad.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 90 citations in OpenAlex.
- Forceful Beginnings: Mechanotransduction and Mechanosensation at the Meiotic Cell Nucleus During Gamete Development.Results and problems in cell differentiation · 2026Review
- Inward transport of organelles drives outward migration of the spindle during C. elegans meiosis.Cell reports · 2025Article
- ZYG-12/Hook's dual role as a dynein adaptor for early endosomes and nuclei is regulated by alternative splicing of its cargo binding domain.Molecular biology of the cell · 2025Article
- Centriole elimination during Caenorhabditis elegans oogenesis initiates with loss of the central tube protein SAS-1.The EMBO journal · 2023Article
- The SUN-like protein TgSLP1 is essential for nuclear division in the apicomplexan parasite Toxoplasma gondii.Journal of cell science · 2023Article
- A cooperative network at the nuclear envelope counteracts LINC-mediated forces during oogenesis inScience advances · 2023Article
- A germline-specific role for unconventional components of the γ-tubulin complex in Caenorhabditis elegans.Journal of cell science · 2023Article
- Actin-capping protein regulates actomyosin contractility to maintain germline architecture in C. elegans.Development (Cambridge, England) · 2023Article
- Molecular architecture of the C. elegans centriole.PLoS biology · 2022Article
- Principles of microtubule polarity in linear cells.Developmental biology · 2022Review
- Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans.PLoS genetics · 2021Article
- A network of nuclear envelope proteins and cytoskeletal force generators mediates movements of and within nuclei throughoutExperimental biology and medicine (Maywood, N.J.) · 2019Review
- Effects of the microtubule nucleator Mto1 on chromosomal movement, DNA repair, and sister chromatid cohesion in fission yeast.Molecular biology of the cell · 2019Article
- Meiotic chromosomes in motion: a perspective from Mus musculus and Caenorhabditis elegans.Chromosoma · 2019Article
- Control of oocyte meiotic maturation in C. elegans.Seminars in cell & developmental biology · 2018Review
- Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis.PLoS genetics · 2018Article
- Genetic Analysis of Nuclear Migration and Anchorage to Study LINC Complexes During Development of Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Moving and stopping: Regulation of chromosome movement to promote meiotic chromosome pairing and synapsis.Nucleus (Austin, Tex.) · 2017Review
- Cytoskeletal variations in an asymmetric cell division support diversity in nematode sperm size and sex ratios.Development (Cambridge, England) · 2017Article
- Microtubule organization, dynamics and functions in differentiated cells.Development (Cambridge, England) · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Changes in cellular microtubule organization often accompany developmental progression. In the Caenorhabditis elegans embryo, the centrosome, which is attached to the nucleus via ZYG-12, organizes the microtubule network. In this study, we investigate ZYG-12 function and microtubule organization before embryo formation in the gonad. Surprisingly, ZYG-12 is dispensable for centrosome attachment in the germline. However, ZYG-12-mediated recruitment of dynein to the nuclear envelope is required to maintain microtubule organization, membrane architecture, and nuclear positioning within the syncytial gonad. We examined gamma-tubulin localization and microtubule regrowth after depolymerization to identify sites of nucleation in germ cells. gamma-Tubulin localizes to the plasma membrane in addition to the centrosome, and regrowth initiates at both sites. Because we do not observe organized microtubules around zyg-12(ct350) mutant nuclei with attached centrosomes, we propose that gonad architecture, including membrane and nuclear positioning, is determined by microtubule nucleation at the plasma membrane combined with tension on the microtubules by dynein anchored at the nucleus by ZYG-12.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.