Evidence map›Paper›PMID 19634033›Full record

ArticleCognitive neuropsychiatry2009

Learning abilities and disabilities: generalist genes in early adolescence.

Oliver S P Davis, Claire M A Haworth, Robert Plomin

Abstract readTwin Study
In one paragraph

Article in Cognitive neuropsychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. A Meta-Analytical Review of the Genetic and Environmental Correlations between Reading and Attention-Deficit Hyperactivity Disorder Symptoms and Reading and Math.Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading · 2020
    Article
  7. The genetics of university success.Scientific reports · 2018
    Article
  8. Review
  9. Genome-Wide Polygenic Scores Predict Reading Performance Throughout the School Years.Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading · 2017
    Article
  10. Top 10 Replicated Findings From Behavioral Genetics.Perspectives on psychological science : a journal of the Association for Psychological Science · 2016
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Evidence for shared genetic risk between ADHD symptoms and reduced mathematics ability: a twin study.Journal of child psychology and psychiatry, and allied disciplines · 2014
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Oliver S P DavisSocial, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK. Oliver.Davis@iop.kcl.ac.uk
Claire M A Haworth
Robert Plomin

Funding

Genetics, School environments and cognitive developmentR01HD044454 · NICHD · KING'S COLLEGE LONDON · PI PLOMIN, ROBERT · 2005 to 2014
$3.4M
GENETICS OF GENERAL AND SPECIFIC MATH DISABILITIESR01HD046167 · NICHD · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI PETRILL, STEPHEN A · 2003 to 2005
$1.6M
Reading disability QTLs: pooled DNA on microarraysR01HD049861 · NICHD · KING'S COLLEGE LONDON · PI PLOMIN, ROBERT · 2006 to 2008
$794k
Medical Research Council G0500079Medical Research Council G0500079(73692)Medical Research Council G19/2Medical Research Council G500079NICHD NIH HHS HD44454NICHD NIH HHS HD46167NICHD NIH HHS HD49861NICHD NIH HHS R01 HD044454NICHD NIH HHS R01 HD046167NICHD NIH HHS R01 HD049861
6 · The paper itself

Abstract

introductionThe new view of cognitive neuropsychology that considers not just case studies of rare severe disorders but also common disorders, as well as normal variation and quantitative traits, is more amenable to recent advances in molecular genetics, such as genome-wide association studies, and advances in quantitative genetics, such as multivariate genetic analysis. A surprising finding emerging from multivariate quantitative genetic studies across diverse learning abilities is that most genetic influences are shared: they are "generalist", rather than "specialist".

methodsWe exploited widespread access to inexpensive and fast Internet connections in the United Kingdom to assess over 5000 pairs of 12-year-old twins from the Twins Early Development Study (TEDS) on four distinct batteries: reading, mathematics, general cognitive ability (g) and, for the first time, language.

resultsGenetic correlations remain high among all of the measured abilities, with language as highly correlated genetically with g as reading and mathematics.

conclusionsDespite developmental upheaval, generalist genes remain important into early adolescence, suggesting optimal strategies for molecular genetic studies seeking to identify the genes of small effect that influence learning abilities and disabilities.

Indexed as

AdolescentChildComprehensionData Interpretation, StatisticalFemaleHumansLanguageLanguage DevelopmentLearningLearning DisabilitiesMaleMathematicsNeuropsychological TestsPhenotypePsycholinguisticsPsychomotor Performance

Identifiers

PMID19634033
PMCPMC2886509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.