ArticleThe international journal of cardiovascular imaging2009
Low fingertip temperature rebound measured by digital thermal monitoring strongly correlates with the presence and extent of coronary artery disease diagnosed by 64-slice multi-detector computed tomography.
Article in The international journal of cardiovascular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 48 citations in OpenAlex.
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- Atherosclerotic cardiovascular disease risk assessment: An American Society for Preventive Cardiology clinical practice statement.American journal of preventive cardiology · 2022Article
- Portable, handheld, and affordable blood perfusion imager for screening of subsurface cancer in resource-limited settings.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Elevated serum thyrotropin levels and endothelial dysfunction in a prospective hemodialysis cohort.Hemodialysis international. International Symposium on Home Hemodialysis · 2022Article
- High Frequency of Microvascular Dysfunction in US Outpatient Clinics: A Sign of High Residual Risk? Data from 7,105 Patients.International journal of vascular medicine · 2022Article
- Digital thermography and vascular involvement in β-thalassemia intermedia.Annals of hematology · 2021Article
- Non-invasive assessment of endothelial dysfunction: A novel method to predict severe COVID-19?Medical hypotheses · 2020Article
- A Paradoxical Vasodilatory Nutraceutical Intervention for Prevention and Attenuation of Migraine-A Hypothetical Review.Nutrients · 2020Review
- Serum Osteocalcin Level is Negatively Associated with Vascular Reactivity Index by Digital Thermal Monitoring in Kidney Transplant Recipients.Medicina (Kaunas, Lithuania) · 2020Article
- The association of nadir CD4-T cell count and endothelial dysfunction in a healthy HIV cohort without major cardiovascular risk factors.SAGE open medicine · 2020Article
- Practicality and importance of selected endothelial dysfunction measurement techniques: review.Biomedical engineering letters · 2019Review
- New Indices of Endothelial Function Measured by Digital Thermal Monitoring of Vascular Reactivity: Data from 6084 Patients Registry.International journal of vascular medicine · 2016Article
- Association of coronary artery calcium score and vascular dysfunction in long-term hemodialysis patients.Hemodialysis international. International Symposium on Home Hemodialysis · 2013Article
- Fingertip digital thermal monitoring: a fingerprint for cardiovascular disease?The international journal of cardiovascular imaging · 2010Article
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10 authors at 5 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Previous studies showed strong correlations between low fingertip temperature rebound measured by digital thermal monitoring (DTM) during a 5 min arm-cuff induced reactive hyperemia and both the Framingham Risk Score (FRS), and coronary artery calcification (CAC) in asymptomatic populations. This study evaluates the correlation between DTM and coronary artery disease (CAD) measured by CT angiography (CTA) in symptomatic patients. It also investigates the correlation between CTA and a new index of neurovascular reactivity measured by DTM. 129 patients, age 63 +/- 9 years, 68% male, underwent DTM, CAC and CTA. Adjusted DTM indices in the occluded arm were calculated: temperature rebound: aTR and area under the temperature curve aTMP-AUC. DTM neurovascular reactivity (NVR) index was measured based on increased fingertip temperature in the non-occluded arm. Obstructive CAD was defined as >or=50% luminal stenosis, and normal as no stenosis and CAC = 0. Baseline fingertip temperature was not different across the groups. However, all DTM indices of vascular and neurovascular reactivity significantly decreased from normal to non-obstructive to obstructive CAD [(aTR 1.77 +/- 1.18 to 1.24 +/- 1.14 to 0.94 +/- 0.92) (P = 0.009), (aTMP-AUC: 355.6 +/- 242.4 to 277.4 +/- 182.4 to 184.4 +/- 171.2) (P = 0.001), (NVR: 161.5 +/- 147.4 to 77.6 +/- 88.2 to 48.8 +/- 63.8) (P = 0.015)]. After adjusting for risk factors, the odds ratio for obstructive CAD compared to normal in the lowest versus two upper tertiles of FRS, aTR, aTMP-AUC, and NVR were 2.41 (1.02-5.93), P = 0.05, 8.67 (2.6-9.4), P = 0.001, 11.62 (5.1-28.7), P = 0.001, and 3.58 (1.09-11.69), P = 0.01, respectively. DTM indices and FRS combined resulted in a ROC curve area of 0.88 for the prediction of obstructive CAD. In patients suspected of CAD, low fingertip temperature rebound measured by DTM significantly predicted CTA-diagnosed obstructive disease.
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