ArticleJournal of neurology2009
An evaluation of the usefulness of neuroimaging for the diagnosis of Japanese encephalitis.
Article in Journal of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Diagnosis and Management of Infectious Encephalitis in Adults: Guidelines From the European Academy of Neurology and European Society of Clinical Microbiology and Infectious Diseases.European journal of neurology · 2026Guideline
- Japanese Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2019Guideline
- Tissue tropism and mRNA expression profiles of selected innate immunity-related genes following experimental tick-borne encephalitis virus and louping ill virus infection of sheep.Journal of virology · 2026Article
- Beyond the borders-coma as a complication of imported Japanese encephalitis: a case report.Journal of medical case reports · 2026Article
- Neuroinvasion of emerging and re-emerging arboviruses: A scoping review.SAGE open medicine · 2024Article
- Who Is at Risk? A Critical Case of Japanese Encephalitis.Journal of acute medicine · 2022Article
- Cognitive decline following acute viral infections: literature review and projections for post-COVID-19.European archives of psychiatry and clinical neuroscience · 2022Review
- Safety of Japanese encephalitis vaccines.Human vaccines & immunotherapeutics · 2021Article
- MRI Spectrum of Japanese Encephalitis in Northeast India: A Cross-Sectional Study.Journal of neurosciences in rural practice · 2021Article
- Leptomeningeal Enhancement without Thalamic Involvement as an Initial Manifestation of Japanese Encephalitis: A Case Report.Taehan Yongsang Uihakhoe chi · 2021Article
- Efficient control of Japanese encephalitis virus in the central nervous system of infected pigs occurs in the absence of a pronounced inflammatory immune response.Journal of neuroinflammation · 2020Article
- 'More than devastating'-patient experiences and neurological sequelae of Japanese encephalitis§.Journal of travel medicine · 2019Article
- Japanese encephalitis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- Japanese encephalitis - the prospects for new treatments.Nature reviews. Neurology · 2018Review
- Herpes simplex encephalitis with thalamic, brainstem and cerebellar involvement.The neuroradiology journal · 2018Article
- Neuroimaging in encephalitis: analysis of imaging findings and interobserver agreement.Clinical radiology · 2016Article
- Bilateral facial palsy as a manifestation of Japanese encephalitis.BMJ case reports · 2012Article
- Clinical and prognostic features among children with acute encephalitis syndrome in Nepal; a retrospective study.BMC infectious diseases · 2011Article
- Bilateral Thalamic Hyperintensities in a case of Viral Encephalitis.Journal of global infectious diseases · 2010Article
- Advances in pediatric neurovirology.Current neurology and neuroscience reports · 2010Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
Japanese encephalitis virus (JEV) is estimated to cause 30–50,000 cases of encephalitis every year. The disease occurs mainly in rural Asia and is transmitted to humans from birds and pigs by mosquitoes of the genus Culex. JE is diagnosed with antibody testing of the serum and CSF, but this is not available in many hospitals. Neuroimaging abnormalities, particularly thalamic hypodensity on computed tomography (CT) and hyperintensity on T2 weighted magnetic resonance imaging (MRI) have been described in case studies, but their usefulness for diagnosing JE is not known. We have therefore evaluated the usefulness of neuroimaging (CT and MRI) for the diagnosis of JE. The findings of thalamic lesions were compared with the final serological diagnosis in a cohort of 75 patients (children and adults) with suspected CNS infections in Southern Vietnam, a JEV endemic area. Thalamic lesions on CT and/or MRI combined had sensitivity 23% (95% confidence interval 12.9–33.1%), specificity 100%, positive predictive value 100% and negative predictive value 42.1% (95% confidence interval 30.2–53.8%) for a diagnosis of JE in this cohort. Over time, the thalamic lesions resolved in some patients. One patient showed disappearance of lesions on CT followed by reappearance of the lesions some time later, known as the fogging effect. In this setting, the presence of thalamic abnormalities suggested the diagnosis of JE, but their absence did not exclude it.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.