ArticleNeuroscience bulletin2009
An investigation of vitamin B12 deficiency in elderly inpatients in neurology department.
Article in Neuroscience bulletin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Subnormal vitamin B12 concentrations and anaemia in older people: a systematic review.BMC geriatrics · 2010Pooled it
- Role and Relationship Between Homocysteine and HMolecular neurobiology · 2025Review
- Vitamin BBMC geriatrics · 2024Article
- A Retrospective Analysis of Pain Etiology in Middle-Aged Patients with Peripheral Neuropathy.Medicina (Kaunas, Lithuania) · 2021Article
- Optic neuropathy as a presenting feature of vitamin B-12 deficiency: A systematic review of literature and a case report.Annals of medicine and surgery (2012) · 2020Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the status of vitamin B12 deficiency in elderly inpatients in the department of neurology.
methodsA total number of 827 patients in the department of neurology of Shanghai Punan hospital, from March 2007 to July 2008, were employed in the present study. They were 60 years or older, and the average age was 77.1+/-7.5 years old. All the patients were diagnosed with no severe hepatic or renal dysfunction, without any usage of vitamin B12 during the previous 3 months before the detection. The levels of serum vitamin B12, folate and homocysteine (Hcy) were evaluated. The patients with vitamin B12 deficiency were screened. The resulting symptoms, positive signs of neurological examination, and the neuroelectricphysiological results were compared between patients with or without vitamin B12 deficiency.
resultsVitamin B12 deficiency was found in 163 patients (19.71% of the total patients), and was more prevalent in female than in male patients, also with increased incidences with aging. Patients with low levels of serum vitamin B12 exhibited higher rate of gastrointestinal diseases, while only 9.82% of the vitamin B12 deficient patients had megaloblastic anemia. Symptoms of vitamin B12 deficiency included unsteadily walking in the darkness and hypopallesthesia, and some chronic diseases such as cerebral ischemia, hypertension, Parkinson's disease (Parkinsonism), diabetes mellitus and coronary heart disease. Most of the vitamin B12 deficient patients had neuroelectricphysiological abnormalities.
conclusionVitamin B12 deficiency is remarkably common in elderly patients in neurology department, with various and atypical clinical manifestations, and the neurological symptoms are more common than megaloblastic anemia symptoms.
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