ReviewCurrent opinion in infectious diseases2009
Genetics of susceptibility to infection with enteric pathogens.
Review in Current opinion in infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.Human molecular genetics · 2016Pooled it
- Stool microbial composition is associated with recent and future diarrhea and fever events in breastfed Danish infants.mSystems · 2026Observational
- Infectious Diarrhea in Early Childhood across the Global South: Etiologic Diversity and Pathogenic Mechanisms.ACS infectious diseases · 2026Review
- Clostridium perfringens in central Colombia: frequency, toxin genes, and risk factors.Gut pathogens · 2024Article
- Shigella-Controlled Human Infection Models: Current and Future Perspectives.Current topics in microbiology and immunology · 2024Review
- Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection.Scientific reports · 2023Article
- Review
- Assessment of the influence of ABO blood groups on oral cholera vaccine immunogenicity in a cholera endemic area in Zambia.BMC public health · 2023Article
- From modern-day parasitology to paleoparasitology: the elusive past record and evolution ofFrontiers in microbiology · 2023Review
- IL-4 gene polymorphisms and their association with nematodes infection in Pakistani population.African health sciences · 2022Article
- Article
- Immune Response Characterization after Controlled Infection with Lyophilized Shigella sonnei 53G.mSphere · 2020Article
- Direct Sequencing ofFrontiers in public health · 2019Review
- Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression.Frontiers in immunology · 2019Article
- Enterobacteria and host resistance to infection.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Causes of impaired oral vaccine efficacy in developing countries.Future microbiology · 2018Review
- Whole-genome sequencing targets drug-resistant bacterial infections.Human genomics · 2015Review
- Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence.Nature communications · 2015Article
- Looking for Cryptosporidium: the application of advances in detection and diagnosis.Trends in parasitology · 2013Review
- A genomic analysis of Clostridium difficile infections in blunt trauma patients.The journal of trauma and acute care surgery · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThis review examines recent developments in human genetic susceptibility to enteropathogens that cause infectious diarrhea. RECENT
findingsThe affinity of specific norovirus genogroups to different histoblood group antigens (HBGAs) on secretor cells has been studied in different epidemiologic studies. HBGAs are also used as receptors by Vibrio cholerae with different degrees of affinity between biotypes. Polymorphisms in the CD14, lactoferrin and osteoprotegerin promoter genes were associated to diarrhea in travelers. Single nucleotide polymorphisms in the IL-8 genes are also associated to increased risk for enteroaggregative Escherichia coli and Clostridium difficile infection. IL-10 haplotypes were associated to enterotoxigenic E. coli associated diarrhea in exposed individuals. A family-based study showed a significant association of the LPLUNC1 gene and cholera. The major histocompatibility complex class II antigens are associated to different degrees of susceptibility and resistance to Salmonella, Cryptosporidium and Entamoeba infection. SUMMARY: Variants in genes that encode molecules that mediate attachment, pathogen recognition, inflammatory cytokine response, innate and acquired immunity are being identified as determinants of host genetic susceptibility to infectious diarrhea.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.