ArticleApplied and environmental microbiology2009
Contributions of O island 48 to adherence of enterohemorrhagic Escherichia coli O157:H7 to epithelial cells in vitro and in ligated pig ileal loops.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 47 citations in OpenAlex.
- The tellurite resistance gene cluster of pathogenic bacteria and its effect on oxidative stress response.Folia microbiologica · 2024Article
- Characterization of the Tellurite-Resistance Properties and Identification of the Core Function Genes for Tellurite Resistance inMicroorganisms · 2022Article
- Diversity of the Tellurite Resistance Gene Operon inFrontiers in microbiology · 2021Article
- Magnesium Sensing Regulates Intestinal Colonization of Enterohemorrhagic Escherichia coli O157:H7.mBio · 2020Article
- Pathogenicity Factors of Genomic Islands in Intestinal and ExtraintestinalFrontiers in microbiology · 2020Review
- LysR-type transcriptional regulator OvrB encoded in O island 9 drives enterohemorrhagicVirulence · 2019Article
- Identification and detection ofHeliyon · 2019Article
- Molecular profiling and antimicrobial resistance of Shiga toxin-producing Escherichia coli O26, O45, O103, O121, O145 and O157 isolates from cattle on cow-calf operations in South Africa.Scientific reports · 2019Article
- The Prophages ofJournal of bacteriology · 2019Article
- Quantification of enterohemorrhagic Escherichia coli O157:H7 protein abundance by high-throughput proteome.PloS one · 2018Article
- Transcriptional Activator GmrA, Encoded in Genomic Island OI-29, Controls the Motility of EnterohemorrhagicFrontiers in microbiology · 2018Article
- Corynebacterium diphtheriae putative tellurite-resistance protein (CDCE8392_0813) contributes to the intracellular survival in human epithelial cells and lethality of Caenorhabditis elegans.Memorias do Instituto Oswaldo Cruz · 2015Article
- Molecular hazard identification of non-O157 Shiga toxin-producing Escherichia coli (STEC).PloS one · 2015Article
- Construction and characterization of tetH overexpression and knockout strains of Acidithiobacillus ferrooxidans.Journal of bacteriology · 2014Article
- The Escherichia coli O157:H7 bovine rumen fluid proteome reflects adaptive bacterial responses.BMC microbiology · 2014Article
- Lineage-specific distribution of insertion sequence excision enhancer in enterotoxigenic Escherichia coli isolated from swine.Applied and environmental microbiology · 2014Article
- Emerging types of Shiga toxin-producing E. coli (STEC) O178 present in cattle, deer, and humans from Argentina and Germany.Frontiers in cellular and infection microbiology · 2014Article
- Distribution of pathogenicity islands OI-122, OI-43/48, and OI-57 and a high-pathogenicity island in Shiga toxin-producing Escherichia coli.Applied and environmental microbiology · 2013Article
- Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence.Frontiers in cellular and infection microbiology · 2013Review
- An O island 172 encoded RNA helicase regulates the motility of Escherichia coli O157:H7.PloS one · 2013Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
O island 48 (OI-48) of Escherichia coli consists of three functional gene clusters that encode urease, tellurite resistance (Te(r)), and putative adhesins Iha and AIDA-1. The functions of these clusters in enterohemorrhagic E. coli (EHEC) O157:H7 infection are unknown. Deletion mutants for these three regions were constructed and evaluated for their ability to adhere to epithelial cells in vitro and in ligated pig ileal loops. Deletion of the Te(r) gene cluster reduced the ability of the organism to adhere to and form large clusters on IPEC-J2 and HEp-2 cells. Complementation of the mutation by introducing the wild-type ter genes restored adherence and large-cluster formation. Tests in ligated pig ileal loops showed a decrease in colonization by the Te(r)-negative mutant, but the difference was not significant compared to colonization by the wild type (26.4% +/- 21.2% versus 40.1% +/- 19.1%; P = 0.168). The OI-48 aidA gene deletion had no effect on adherence in vitro or in vivo. Deletion of the iha and ureC genes had no effect on adherence in vitro but significantly reduced the colonization of EHEC O157:H7 in the ligated pig intestine. These data suggest that Te(r), Iha, and urease may contribute to EHEC O157:H7 pathogenesis by promoting adherence of the pathogen to the host intestinal epithelium.
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