ArticleJournal of bacteriology2009
Characterization and comparative analysis of the genes encoding Haemophilus parasuis outer membrane proteins P2 and P5.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Molecular characterization of Glaesserella parasuis strains circulating in North American swine production systems.BMC veterinary research · 2023Article
- Molecular Characterization and Phylogenetic Analysis ofPathogens (Basel, Switzerland) · 2023Article
- Screening of linear B-cell epitopes and its proinflammatory activities ofFrontiers in cellular and infection microbiology · 2023Article
- Immunogenicity and protection against Glaesserella parasuis serotype 13 infection after vaccination with recombinant protein LolA in mice.The Journal of veterinary medical science · 2022Article
- Surface-exposed loops L7 and L8 of Haemophilus (Glaesserella) parasuis OmpP2 contribute to the expression of proinflammatory cytokines in porcine alveolar macrophages.Veterinary research · 2019Article
- Comparison of multilocus sequence types found among North American isolates ofJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019Article
- Association betweenPeerJ · 2019Article
- Characterization and Vaccine Potential of Outer Membrane Vesicles Produced by Haemophilus parasuis.PloS one · 2016Article
- Article
- Draft Genome Sequences for 10 Isolates of the Swine Pathogen Haemophilus parasuis.Genome announcements · 2013Article
- Virulence, transmission, and heterologous protection of four isolates of Haemophilus parasuis.Clinical and vaccine immunology : CVI · 2013Article
- Cross-protective efficacy of recombinant transferrin-binding protein A of Haemophilus parasuis in guinea pigs.Clinical and vaccine immunology : CVI · 2013Article
- Molecular typing methods for outbreak detection and surveillance of invasive disease caused by Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae, a review.Microbiology (Reading, England) · 2011Review
- Nontypable Haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates.PloS one · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Haemophilus parasuis is a swine pathogen of significant industry concern, but little is known about how the organism causes disease. A related human pathogen, Haemophilus influenzae, has been better studied, and many of its virulence factors have been identified. Two of these, outer membrane proteins P2 and P5, are known to have important virulence properties. The goals of this study were to identify, analyze, and compare the genetic relatedness of orthologous genes encoding P2 and P5 proteins in a diverse group of 35 H. parasuis strains. Genes encoding P2 and P5 proteins were detected in all H. parasuis strains evaluated. The predicted amino acid sequences for both P2 and P5 proteins exhibit considerable heterogeneity, particularly in regions corresponding to predicted extracellular loops. Twenty-five variants of P2 and 17 variants of P5 were identified. The P2 proteins of seven strains were predicted to contain a highly conserved additional extracellular loop compared to the remaining strains and to H. influenzae P2. Antigenic-site predictions coincided with predicted extracellular loop regions of both P2 and P5. Neighbor-joining trees constructed using P2 and P5 sequences predicted divergent evolutionary histories distinct from those predicted by a multilocus sequence typing phylogeny based on partial sequencing of seven housekeeping genes. Real-time reverse transcription-PCR indicated that both genes are expressed in all of the strains.
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Registered trials
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